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A Novel 2-Metagene Signature to Identify High-Risk HNSCC Patients amongst Those Who Are Clinically at Intermediate Risk and Are Treated with PORT.

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Title: A Novel 2-Metagene Signature to Identify High-Risk HNSCC Patients amongst Those Who Are Clinically at Intermediate Risk and Are Treated with PORT.
Authors: Patil S; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), partner site Dresden, 01307 Dresden, Germany.; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and UniversityHospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.; Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany., Linge A; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), partner site Dresden, 01307 Dresden, Germany.; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and UniversityHospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01307 Dresden, Germany., Hiepe H; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and UniversityHospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany., Grosser M; Institute of Pathology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany., Lohaus F; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), partner site Dresden, 01307 Dresden, Germany.; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and UniversityHospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01307 Dresden, Germany., Gudziol V; Department of Otorhinolaryngology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.; Department of Otorhinolaryngology, Head and Neck Surgery, Municipal Hospital Dresden, 01067 Dresden, Germany., Kemper M; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01307 Dresden, Germany.; Department of Otorhinolaryngology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany., Nowak A; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01307 Dresden, Germany.; Department of Oral and Maxillofacial Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany., Haim D; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01307 Dresden, Germany.; Department of Oral and Maxillofacial Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany., Tinhofer I; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Berlin, 10117 Berlin, Germany.; Department of Radiooncology and Radiotherapy, Charité University Medicine Berlin, 10117 Berlin, Germany., Budach V; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Berlin, 10117 Berlin, Germany.; Department of Radiooncology and Radiotherapy, Charité University Medicine Berlin, 10117 Berlin, Germany., Guberina M; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen, 45147 Essen, Germany.; Department of Radiation Therapy, University Hospital, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany., Stuschke M; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen, 45147 Essen, Germany.; Department of Radiation Therapy, University Hospital, Medical Faculty, University of Duisburg-Essen, 45147 Essen, Germany., Balermpas P; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Frankfurt, 60590 Frankfurt, Germany.; Department of Radiotherapy and Oncology, Goethe-University Frankfurt, 60590 Frankfurt, Germany., Grün JV; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Frankfurt, 60590 Frankfurt, Germany.; Department of Radiotherapy and Oncology, Goethe-University Frankfurt, 60590 Frankfurt, Germany., Schäfer H; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Freiburg, 79106 Freiburg, Germany.; Department of Radiation Oncology, Medical Center, Medical Faculty, University of Freiburg, 79106 Freiburg, Germany., Grosu AL; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Freiburg, 79106 Freiburg, Germany.; Department of Radiation Oncology, Medical Center, Medical Faculty, University of Freiburg, 79106 Freiburg, Germany., Abdollahi A; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Heidelberg, 69120 Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), University of Heidelberg Medical School and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Heidelberg Ion Therapy Center (HIT), Department of Radiation Oncology, University of Heidelberg Medical School, 69120 Heidelberg, Germany.; National Center for Tumor Diseases (NCT), University of Heidelberg Medical School and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Translational Radiation Oncology, University of Heidelberg Medical School and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Debus J; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Heidelberg, 69120 Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), University of Heidelberg Medical School and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Heidelberg Ion Therapy Center (HIT), Department of Radiation Oncology, University of Heidelberg Medical School, 69120 Heidelberg, Germany.; National Center for Tumor Diseases (NCT), University of Heidelberg Medical School and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Clinical Cooperation Unit Radiation Oncology, University of Heidelberg Medical School and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Ganswindt U; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Munich, 80336 Munich, Germany.; Department of Radiotherapy and Radiation Oncology, University Hospital, Ludwig-Maximilians-Universität, 81377 Munich, Germany., Belka C; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Munich, 80336 Munich, Germany.; Department of Radiotherapy and Radiation Oncology, University Hospital, Ludwig-Maximilians-Universität, 81377 Munich, Germany.; Clinical Cooperation Group Personalized Radiotherapy in Head and Neck Cancer, Helmholtz Zentrum Munich, 85764 Neuherberg, Germany., Pigorsch S; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Munich, 80336 Munich, Germany.; Department of Radiation Oncology, Technische Universität München, 81675 Munich, Germany., Combs SE; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Munich, 80336 Munich, Germany.; Department of Radiation Oncology, Technische Universität München, 81675 Munich, Germany.; Department of Radiation Sciences (DRS), Institut für Innovative Radiotherapie (iRT), Helmholtz Zentrum Munich, 85764 Neuherberg, Germany., Boeke S; German Cancer Research Center (DKFZ), 60120 Heidelberg, Germany and German Cancer Consortium (DKTK), partner site Tübingen, 72076 Tübingen, Germany.; Department of Radiation Oncology, Faculty of Medicine and University Hospital Tübingen, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany., Zips D; German Cancer Research Center (DKFZ), 60120 Heidelberg, Germany and German Cancer Consortium (DKTK), partner site Tübingen, 72076 Tübingen, Germany.; Department of Radiation Oncology, Faculty of Medicine and University Hospital Tübingen, Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany., Jöhrens K; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), partner site Dresden, 01307 Dresden, Germany.; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01307 Dresden, Germany.; Institute of Pathology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany., Baretton GB; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), partner site Dresden, 01307 Dresden, Germany.; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01307 Dresden, Germany.; Institute of Pathology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.; Tumor- and Normal Tissue Bank, University Cancer Centre (UCC), University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany., Baumann M; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and UniversityHospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Krause M; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), partner site Dresden, 01307 Dresden, Germany.; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and UniversityHospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.; Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01307 Dresden, Germany., Löck S; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), partner site Dresden, 01307 Dresden, Germany.; OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and UniversityHospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, 01307 Dresden, Germany.; Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.; National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany: German Cancer Research Center (DKFZ), Heidelberg, Germany; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany; Helmholtz Association/Helmholtz-Zentrum Dresden-Rossendorf (HZDR), 01307 Dresden, Germany., On Behalf Of The Dktk-Rog
Source: Cancers [Cancers (Basel)] 2022 Jun 20; Vol. 14 (12). Date of Electronic Publication: 2022 Jun 20.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:2072-6694
DOI:10.3390/cancers14123031