Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation.
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| Title: | Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation. |
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| Authors: | Revie NM; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Iyer KR; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Maxson ME; Program in Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada., Zhang J; Department of Chemistry, Roger Adams Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Yan S; Department of Chemistry, Roger Adams Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Fernandes CM; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA., Meyer KJ; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Chen X; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, L8S 4K1, Canada., Skulska I; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada., Fogal M; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada., Sanchez H; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA., Hossain S; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Li S; Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, Toronto, ON, Canada., Yashiroda Y; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan., Hirano H; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan., Yoshida M; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan.; Department of Biotechnology, Graduate School of Agricultural Life Sciences, The University of Tokyo, Tokyo, Japan.; Collaborative Research Institute for Innovative Microbiology, The University of Tokyo, Tokyo, Japan., Osada H; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan., Boone C; Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, Toronto, ON, Canada.; RIKEN Center for Sustainable Resource Science, Wako, Saitama, Japan., Shapiro RS; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada., Andes DR; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.; Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA., Wright GD; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, L8S 4K1, Canada., Nodwell JR; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Del Poeta M; Department of Microbiology and Immunology, Stony Brook University, Stony Brook, NY, USA.; Division of Infectious Diseases, Stony Brook University, Stony Brook, NY, USA.; Veteran Administration Medical Center, Northport, NY, USA., Burke MD; Department of Chemistry, Roger Adams Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Department of Biochemistry, Roger Adams Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, USA.; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA., Whitesell L; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Robbins N; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Cowen LE; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. leah.cowen@utoronto.ca. |
| Source: | Nature communications [Nat Commun] 2022 Jun 25; Vol. 13 (1), pp. 3634. Date of Electronic Publication: 2022 Jun 25. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-022-31308-1 |
