Pre-existing Reactivity to an IgG4 Fc-Epitope: Characterization and Mitigation of Interference in a Bridging Anti-drug Antibody Assay.
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| Title: | Pre-existing Reactivity to an IgG4 Fc-Epitope: Characterization and Mitigation of Interference in a Bridging Anti-drug Antibody Assay. |
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| Authors: | Partridge MA; Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA. michael.partridge@regeneron.com., Chen J; Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA., Karayusuf EK; Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA., Sirimanne T; Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA., Stefan C; Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA., Lai CH; Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA., Gathani M; Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA., DeStefano L; Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA., Rozanski M; Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA., McAfee S; Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA., Rajadhyaksha M; Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.; Alexion-AstraZeneca Rare Disease Unit, 100 College St, New Haven, CT, 06510, USA., Andisik MD; Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA., Torri A; Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA., Sumner G; Bioanalytical Sciences, Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA. |
| Source: | The AAPS journal [AAPS J] 2022 Jul 01; Vol. 24 (4), pp. 78. Date of Electronic Publication: 2022 Jul 01. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1550-7416 |
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| DOI: | 10.1208/s12248-022-00729-7 |
