Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities.

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Bibliographic Details
Title: Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities.
Authors: Ho SWT; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Sheng T; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Biochemistry, National University of Singapore, Singapore., Xing M; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ooi WF; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Xu C; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Sundar R; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, National University Hospital, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore., Huang KK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Li Z; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore., Kumar V; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ramnarayanan K; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Zhu F; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Srivastava S; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Isa ZFBA; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Anene-Nzelu CG; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Montreal Heart Institute, Quebec, Quebec, Canada.; Department of Medicine, University of Montreal, Quebec, Quebec, Canada., Razavi-Mohseni M; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Shigaki D; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Ma H; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Tan ALK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ong X; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Lee MH; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Tay ST; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Guo YA; Computational and Systems Biology, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Huang W; Computational and Systems Biology, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Li S; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Beer MA; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Foo RSY; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Teh M; Department of Pathology, National University of Singapore, Singapore., Skanderup AJ; Computational and Systems Biology, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Teh BT; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore.; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore., Tan P; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore gmstanp@duke-nus.edu.sg.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cellular and Molecular Research, National Cancer Centre, Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore.
Source: Gut [Gut] 2023 Feb; Vol. 72 (2), pp. 226-241. Date of Electronic Publication: 2022 Jul 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1468-3288
DOI:10.1136/gutjnl-2021-326483