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Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction.

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Title: Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction.
Authors: Ketcham JM; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Haling J; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Khare S; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Bowcut V; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Briere DM; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Burns AC; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Gunn RJ; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Ivetac A; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Kuehler J; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Kulyk S; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Laguer J; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Lawson JD; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Moya K; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Nguyen N; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Rahbaek L; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Saechao B; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Smith CR; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Sudhakar N; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Thomas NC; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Vegar L; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Vanderpool D; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Wang X; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Yan L; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Olson P; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Christensen JG; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Marx MA; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2022 Jul 28; Vol. 65 (14), pp. 9678-9690. Date of Electronic Publication: 2022 Jul 14.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.2c00741