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Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction.

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Title: Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction.
Authors: Ketcham JM; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Haling J; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Khare S; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Bowcut V; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Briere DM; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Burns AC; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Gunn RJ; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Ivetac A; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Kuehler J; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Kulyk S; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Laguer J; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Lawson JD; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Moya K; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Nguyen N; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Rahbaek L; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Saechao B; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Smith CR; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Sudhakar N; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Thomas NC; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Vegar L; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Vanderpool D; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Wang X; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Yan L; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Olson P; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Christensen JG; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States., Marx MA; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2022 Jul 28; Vol. 65 (14), pp. 9678-9690. Date of Electronic Publication: 2022 Jul 14.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design and Discovery of MRTX0902, a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction.
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  Data: <searchLink fieldCode="AU" term="%22Ketcham+JM%22">Ketcham JM</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Haling+J%22">Haling J</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Khare+S%22">Khare S</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Bowcut+V%22">Bowcut V</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Briere+DM%22">Briere DM</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Burns+AC%22">Burns AC</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Gunn+RJ%22">Gunn RJ</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Ivetac+A%22">Ivetac A</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Kuehler+J%22">Kuehler J</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Kulyk+S%22">Kulyk S</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Laguer+J%22">Laguer J</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Lawson+JD%22">Lawson JD</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Moya+K%22">Moya K</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Nguyen+N%22">Nguyen N</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Rahbaek+L%22">Rahbaek L</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Saechao+B%22">Saechao B</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Smith+CR%22">Smith CR</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Sudhakar+N%22">Sudhakar N</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Thomas+NC%22">Thomas NC</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Vegar+L%22">Vegar L</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Vanderpool+D%22">Vanderpool D</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Yan+L%22">Yan L</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Olson+P%22">Olson P</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Christensen+JG%22">Christensen JG</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Marx+MA%22">Marx MA</searchLink>; Mirati Therapeutics, 3545 Cray Court, San Diego, California 92121, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2022 Jul 28; Vol. 65 (14), pp. 9678-9690. <i>Date of Electronic Publication: </i>2022 Jul 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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