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Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma.

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Title: Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma.
Authors: Thadathil N; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Selvarani R; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Mohammed S; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Nicklas EH; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Tran AL; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Kamal M; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Luo W; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Brown JL; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma, USA., Lawrence MM; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.; Department of Kinesiology and Outdoor Recreation, Southern Utah University, Cedar City, Utah, USA., Borowik AK; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA., Miller BF; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma, USA.; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Van Remmen H; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma, USA.; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Richardson A; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma, USA.; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA., Deepa SS; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
Source: Aging cell [Aging Cell] 2022 Aug; Vol. 21 (8), pp. e13676. Date of Electronic Publication: 2022 Jul 23.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Thadathil+N%22">Thadathil N</searchLink>; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Selvarani+R%22">Selvarani R</searchLink>; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Mohammed+S%22">Mohammed S</searchLink>; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Nicklas+EH%22">Nicklas EH</searchLink>; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Tran+AL%22">Tran AL</searchLink>; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Kamal+M%22">Kamal M</searchLink>; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Luo+W%22">Luo W</searchLink>; Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Brown+JL%22">Brown JL</searchLink>; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Lawrence+MM%22">Lawrence MM</searchLink>; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.; Department of Kinesiology and Outdoor Recreation, Southern Utah University, Cedar City, Utah, USA.<br /><searchLink fieldCode="AU" term="%22Borowik+AK%22">Borowik AK</searchLink>; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Miller+BF%22">Miller BF</searchLink>; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma, USA.; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Van+Remmen+H%22">Van Remmen H</searchLink>; Aging & Metabolism Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma, USA.; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Richardson+A%22">Richardson A</searchLink>; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.; Oklahoma City VA Medical Center, Oklahoma City, Oklahoma, USA.; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.<br /><searchLink fieldCode="AU" term="%22Deepa+SS%22">Deepa SS</searchLink>; Department of Biochemistry & Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.; Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
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  Data: <searchLink fieldCode="JN" term="%22101130839%22">Aging cell</searchLink> [Aging Cell] 2022 Aug; Vol. 21 (8), pp. e13676. <i>Date of Electronic Publication: </i>2022 Jul 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-Blackwell%22">Wiley-Blackwell </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101130839 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-9726 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214749718%22">14749718 </searchLink><i>NLM ISO Abbreviation: </i>Aging Cell <i>Subsets: </i>MEDLINE
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      – TitleFull: Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma.
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              Text: 2022 Aug
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