Specific CD4+ T Cell Responses to Ancestral SARS-CoV-2 in Children Increase With Age and Show Cross-Reactivity to Beta Variant.

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Title: Specific CD4+ T Cell Responses to Ancestral SARS-CoV-2 in Children Increase With Age and Show Cross-Reactivity to Beta Variant.
Authors: Paul K; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sibbertsen F; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States., Lütgehetmann M; Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; German Center for Infection Research, partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Barroso M; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Danecka MK; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Glau L; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hecher L; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hermann K; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kohl A; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Oh J; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schulze Zur Wiesch J; German Center for Infection Research, partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.; First Department of Medicine, Division of Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, United States., Tolosa E; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Vettorazzi E; Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Woidy M; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zapf A; Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zazara DE; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division for Experimental Feto-Maternal Medicine, Department of Obstetrics and Prenatal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mir TS; Department of Pediatric Cardiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Muntau AC; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Gersting SW; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Dunay GA; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Source: Frontiers in immunology [Front Immunol] 2022 Jul 15; Vol. 13, pp. 867577. Date of Electronic Publication: 2022 Jul 15 (Print Publication: 2022).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1664-3224
DOI:10.3389/fimmu.2022.867577