Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity.
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| Title: | Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity. |
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| Authors: | Möhrmann L; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany., Werner M; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany., Oleś M; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany., Mock A; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Department of Medical Oncology, NCT Heidelberg and Heidelberg University Hospital, Heidelberg, Germany., Uhrig S; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Jahn A; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.; Institute for Clinical Genetics, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Dresden, Germany., Kreutzfeldt S; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany., Fröhlich M; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Hutter B; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Paramasivam N; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Richter D; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Dresden, Germany., Beck K; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Winter U; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Pfütze K; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Heilig CE; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany., Teleanu V; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany., Lipka DB; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Section Translational Cancer Epigenomics, Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany., Zapatka M; Division of Molecular Genetics, DKFZ, Heidelberg, Germany., Hanf D; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany., List C; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany., Allgäuer M; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Penzel R; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Rüter G; Charité Comprehensive Cancer Center, Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Jelas I; Charité Comprehensive Cancer Center, Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Hamacher R; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.; DKTK, Essen, Germany., Falkenhorst J; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.; DKTK, Essen, Germany., Wagner S; Department of Medicine 2, Hematology/Oncology, Goethe University, Frankfurt, Germany.; DKTK, Frankfurt, Germany., Brandts CH; Department of Medicine 2, Hematology/Oncology, Goethe University, Frankfurt, Germany.; DKTK, Frankfurt, Germany., Boerries M; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.; DKTK, Freiburg, Germany., Illert AL; DKTK, Freiburg, Germany.; Department of Internal Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Metzeler KH; Department of Internal Medicine III, University Hospital, LMU Munich and Comprehensive Cancer Center, Munich, Germany.; Department of Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany., Westphalen CB; Department of Internal Medicine III, University Hospital, LMU Munich and Comprehensive Cancer Center, Munich, Germany., Desuki A; University Cancer Center Mainz, University Medical Center Mainz, Mainz, Germany.; DKTK, Mainz, Germany., Kindler T; University Cancer Center Mainz, University Medical Center Mainz, Mainz, Germany.; DKTK, Mainz, Germany., Folprecht G; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany., Weichert W; Institute of Pathology, Technical University Munich, Munich, Germany., Brors B; Division of Applied Bioinformatics, NCT Heidelberg and DKFZ, Heidelberg, Germany., Stenzinger A; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Schröck E; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.; Institute for Clinical Genetics, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Dresden, Germany., Hübschmann D; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany.; Pattern Recognition and Digital Medicine, Heidelberg Institute for Stem cell Technology and Experimental Medicine, Heidelberg, Germany.; DKTK, Heidelberg, Germany., Horak P; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.; DKTK, Heidelberg, Germany., Heining C; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany., Fröhling S; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.; DKTK, Heidelberg, Germany., Glimm H; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany. hanno.glimm@nct-dresden.de.; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany. hanno.glimm@nct-dresden.de.; German Cancer Consortium (DKTK), Dresden, Germany. hanno.glimm@nct-dresden.de.; Translational Functional Cancer Genomics, NCT Heidelberg and DKFZ, Heidelberg, Germany. hanno.glimm@nct-dresden.de. |
| Source: | Nature communications [Nat Commun] 2022 Aug 02; Vol. 13 (1), pp. 4485. Date of Electronic Publication: 2022 Aug 02. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-022-31866-4 |
