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Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity.

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Title: Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity.
Authors: Möhrmann L; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany., Werner M; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany., Oleś M; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany., Mock A; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Department of Medical Oncology, NCT Heidelberg and Heidelberg University Hospital, Heidelberg, Germany., Uhrig S; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Jahn A; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.; Institute for Clinical Genetics, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Dresden, Germany., Kreutzfeldt S; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany., Fröhlich M; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Hutter B; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Paramasivam N; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Richter D; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Dresden, Germany., Beck K; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Winter U; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Pfütze K; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany., Heilig CE; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany., Teleanu V; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany., Lipka DB; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Section Translational Cancer Epigenomics, Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany., Zapatka M; Division of Molecular Genetics, DKFZ, Heidelberg, Germany., Hanf D; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany., List C; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany., Allgäuer M; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Penzel R; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Rüter G; Charité Comprehensive Cancer Center, Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Jelas I; Charité Comprehensive Cancer Center, Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Hamacher R; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.; DKTK, Essen, Germany., Falkenhorst J; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.; DKTK, Essen, Germany., Wagner S; Department of Medicine 2, Hematology/Oncology, Goethe University, Frankfurt, Germany.; DKTK, Frankfurt, Germany., Brandts CH; Department of Medicine 2, Hematology/Oncology, Goethe University, Frankfurt, Germany.; DKTK, Frankfurt, Germany., Boerries M; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.; DKTK, Freiburg, Germany., Illert AL; DKTK, Freiburg, Germany.; Department of Internal Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Metzeler KH; Department of Internal Medicine III, University Hospital, LMU Munich and Comprehensive Cancer Center, Munich, Germany.; Department of Hematology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany., Westphalen CB; Department of Internal Medicine III, University Hospital, LMU Munich and Comprehensive Cancer Center, Munich, Germany., Desuki A; University Cancer Center Mainz, University Medical Center Mainz, Mainz, Germany.; DKTK, Mainz, Germany., Kindler T; University Cancer Center Mainz, University Medical Center Mainz, Mainz, Germany.; DKTK, Mainz, Germany., Folprecht G; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany., Weichert W; Institute of Pathology, Technical University Munich, Munich, Germany., Brors B; Division of Applied Bioinformatics, NCT Heidelberg and DKFZ, Heidelberg, Germany., Stenzinger A; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Schröck E; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.; Institute for Clinical Genetics, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Dresden, Germany., Hübschmann D; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany.; Pattern Recognition and Digital Medicine, Heidelberg Institute for Stem cell Technology and Experimental Medicine, Heidelberg, Germany.; DKTK, Heidelberg, Germany., Horak P; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.; DKTK, Heidelberg, Germany., Heining C; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany., Fröhling S; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.; DKTK, Heidelberg, Germany., Glimm H; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany. hanno.glimm@nct-dresden.de.; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany. hanno.glimm@nct-dresden.de.; German Cancer Consortium (DKTK), Dresden, Germany. hanno.glimm@nct-dresden.de.; Translational Functional Cancer Genomics, NCT Heidelberg and DKFZ, Heidelberg, Germany. hanno.glimm@nct-dresden.de.
Source: Nature communications [Nat Commun] 2022 Aug 02; Vol. 13 (1), pp. 4485. Date of Electronic Publication: 2022 Aug 02.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity.
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  Data: <searchLink fieldCode="AU" term="%22Möhrmann+L%22">Möhrmann L</searchLink>; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Werner+M%22">Werner M</searchLink>; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Oleś+M%22">Oleś M</searchLink>; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Mock+A%22">Mock A</searchLink>; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Department of Medical Oncology, NCT Heidelberg and Heidelberg University Hospital, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Uhrig+S%22">Uhrig S</searchLink>; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Jahn+A%22">Jahn A</searchLink>; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.; Institute for Clinical Genetics, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Kreutzfeldt+S%22">Kreutzfeldt S</searchLink>; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Fröhlich+M%22">Fröhlich M</searchLink>; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hutter+B%22">Hutter B</searchLink>; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Paramasivam+N%22">Paramasivam N</searchLink>; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Richter+D%22">Richter D</searchLink>; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Beck+K%22">Beck K</searchLink>; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Winter+U%22">Winter U</searchLink>; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Pfütze+K%22">Pfütze K</searchLink>; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Heilig+CE%22">Heilig CE</searchLink>; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Teleanu+V%22">Teleanu V</searchLink>; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Lipka+DB%22">Lipka DB</searchLink>; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Section Translational Cancer Epigenomics, Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zapatka+M%22">Zapatka M</searchLink>; Division of Molecular Genetics, DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hanf+D%22">Hanf D</searchLink>; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22List+C%22">List C</searchLink>; Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Allgäuer+M%22">Allgäuer M</searchLink>; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Penzel+R%22">Penzel R</searchLink>; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Rüter+G%22">Rüter G</searchLink>; Charité Comprehensive Cancer Center, Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Jelas+I%22">Jelas I</searchLink>; Charité Comprehensive Cancer Center, Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Hamacher+R%22">Hamacher R</searchLink>; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.; DKTK, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Falkenhorst+J%22">Falkenhorst J</searchLink>; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany.; DKTK, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Wagner+S%22">Wagner S</searchLink>; Department of Medicine 2, Hematology/Oncology, Goethe University, Frankfurt, Germany.; DKTK, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Brandts+CH%22">Brandts CH</searchLink>; 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Department of Internal Medicine III, University Hospital, LMU Munich and Comprehensive Cancer Center, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Desuki+A%22">Desuki A</searchLink>; University Cancer Center Mainz, University Medical Center Mainz, Mainz, Germany.; DKTK, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Kindler+T%22">Kindler T</searchLink>; University Cancer Center Mainz, University Medical Center Mainz, Mainz, Germany.; DKTK, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Folprecht+G%22">Folprecht G</searchLink>; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Weichert+W%22">Weichert W</searchLink>; Institute of Pathology, Technical University Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Brors+B%22">Brors B</searchLink>; Division of Applied Bioinformatics, NCT Heidelberg and DKFZ, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Stenzinger+A%22">Stenzinger A</searchLink>; Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Schröck+E%22">Schröck E</searchLink>; Center for Personalized Oncology, NCT Dresden and University Hospital Carl Gustav Carus, Faculty of Medicine and Technische Universität Dresden, Dresden, Germany.; German Cancer Consortium (DKTK), Dresden, Germany.; Institute for Clinical Genetics, University Hospital Carl Gustav Carus Dresden, Technische Universität Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Hübschmann+D%22">Hübschmann D</searchLink>; Computational Oncology Group, NCT Heidelberg and DKFZ, Heidelberg, Germany.; Molecular Precision Oncology Program, NCT Heidelberg, Heidelberg, Germany.; Pattern Recognition and Digital Medicine, Heidelberg Institute for Stem cell Technology and Experimental Medicine, Heidelberg, Germany.; DKTK, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Horak+P%22">Horak P</searchLink>; Department of Translational Medical Oncology, NCT Heidelberg and DKFZ, Heidelberg, Germany.; 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German Cancer Consortium (DKTK), Dresden, Germany. hanno.glimm@nct-dresden.de.; Translational Functional Cancer Genomics, NCT Heidelberg and DKFZ, Heidelberg, Germany. hanno.glimm@nct-dresden.de.
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      – BibEntity:
          Dates:
            – D: 02
              M: 08
              Text: 2022 Aug 02
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 13
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1