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Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors.

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Bibliographic Details
Title: Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors.
Authors: Smith CR; Mirati Therapeutics, San Diego, CA 92121, United States. Electronic address: smithc@mirati.com., Aranda R; Mirati Therapeutics, San Diego, CA 92121, United States., Christensen JG; Mirati Therapeutics, San Diego, CA 92121, United States., Engstrom LD; Mirati Therapeutics, San Diego, CA 92121, United States., Gunn RJ; Mirati Therapeutics, San Diego, CA 92121, United States., Ivetac A; Mirati Therapeutics, San Diego, CA 92121, United States., Ketcham JM; Mirati Therapeutics, San Diego, CA 92121, United States., Kuehler J; Mirati Therapeutics, San Diego, CA 92121, United States., David Lawson J; Mirati Therapeutics, San Diego, CA 92121, United States., Marx MA; Mirati Therapeutics, San Diego, CA 92121, United States., Olson P; Mirati Therapeutics, San Diego, CA 92121, United States., Thomas NC; Mirati Therapeutics, San Diego, CA 92121, United States., Wang X; Mirati Therapeutics, San Diego, CA 92121, United States., Waters LM; Mirati Therapeutics, San Diego, CA 92121, United States., Kulyk S; Mirati Therapeutics, San Diego, CA 92121, United States. Electronic address: kulyks@mirati.com.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Oct 01; Vol. 71, pp. 116947. Date of Electronic Publication: 2022 Jul 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1464-3391
DOI:10.1016/j.bmc.2022.116947