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Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors.

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Title: Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors.
Authors: Smith CR; Mirati Therapeutics, San Diego, CA 92121, United States. Electronic address: smithc@mirati.com., Aranda R; Mirati Therapeutics, San Diego, CA 92121, United States., Christensen JG; Mirati Therapeutics, San Diego, CA 92121, United States., Engstrom LD; Mirati Therapeutics, San Diego, CA 92121, United States., Gunn RJ; Mirati Therapeutics, San Diego, CA 92121, United States., Ivetac A; Mirati Therapeutics, San Diego, CA 92121, United States., Ketcham JM; Mirati Therapeutics, San Diego, CA 92121, United States., Kuehler J; Mirati Therapeutics, San Diego, CA 92121, United States., David Lawson J; Mirati Therapeutics, San Diego, CA 92121, United States., Marx MA; Mirati Therapeutics, San Diego, CA 92121, United States., Olson P; Mirati Therapeutics, San Diego, CA 92121, United States., Thomas NC; Mirati Therapeutics, San Diego, CA 92121, United States., Wang X; Mirati Therapeutics, San Diego, CA 92121, United States., Waters LM; Mirati Therapeutics, San Diego, CA 92121, United States., Kulyk S; Mirati Therapeutics, San Diego, CA 92121, United States. Electronic address: kulyks@mirati.com.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Oct 01; Vol. 71, pp. 116947. Date of Electronic Publication: 2022 Jul 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Smith+CR%22">Smith CR</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States. Electronic address: smithc@mirati.com.<br /><searchLink fieldCode="AU" term="%22Aranda+R%22">Aranda R</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Christensen+JG%22">Christensen JG</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Engstrom+LD%22">Engstrom LD</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Gunn+RJ%22">Gunn RJ</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Ivetac+A%22">Ivetac A</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Ketcham+JM%22">Ketcham JM</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Kuehler+J%22">Kuehler J</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22David+Lawson+J%22">David Lawson J</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Marx+MA%22">Marx MA</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Olson+P%22">Olson P</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Thomas+NC%22">Thomas NC</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Waters+LM%22">Waters LM</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States.<br /><searchLink fieldCode="AU" term="%22Kulyk+S%22">Kulyk S</searchLink>; Mirati Therapeutics, San Diego, CA 92121, United States. Electronic address: kulyks@mirati.com.
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  Data: <searchLink fieldCode="JN" term="%229413298%22">Bioorganic & medicinal chemistry</searchLink> [Bioorg Med Chem] 2022 Oct 01; Vol. 71, pp. 116947. <i>Date of Electronic Publication: </i>2022 Jul 26.
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