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Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose.

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Title: Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose.
Authors: Renia L; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. renia_laurent@idlabs.a-star.edu.sg.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. renia_laurent@idlabs.a-star.edu.sg.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. renia_laurent@idlabs.a-star.edu.sg., Goh YS; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Rouers A; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Le Bert N; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Chia WN; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Chavatte JM; National Public Health Laboratory, Singapore, Singapore.; National Centre for Infectious Diseases, Singapore, Singapore., Fong SW; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chang ZW; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Zhuo NZ; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Tay MZ; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chan YH; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Tan CW; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Yeo NK; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Amrun SN; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Huang Y; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Wong JXE; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Hor PX; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Loh CY; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Wang B; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ngoh EZX; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Salleh SNM; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Carissimo G; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Dowla S; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lim AJ; National Public Health Laboratory, Singapore, Singapore.; National Centre for Infectious Diseases, Singapore, Singapore., Zhang J; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Lim JME; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore., Wang CI; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ding Y; National Centre for Infectious Diseases, Singapore, Singapore., Pada S; Ng Teng Fong General Hospital, Singapore, Singapore., Sun LJ; Alexandra Hospital, Singapore, Singapore., Somani J; Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore, Singapore., Lee ES; National healthcare group polyclinic, Jurong, Singapore., Ong DLS; National University Polyclinics, National University of Singapore, Singapore, Singapore., Leo YS; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; National Centre for Infectious Diseases, Singapore, Singapore.; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.; Tan Tock Seng Hospital, Singapore, Singapore., MacAry PA; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Life Sciences Institute, Centre for Life Sciences, National University of Singapore, Singapore, Singapore., Lin RTP; National Public Health Laboratory, Singapore, Singapore.; National Centre for Infectious Diseases, Singapore, Singapore.; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Wang LF; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.; National Centre for Infectious Diseases, Singapore, Singapore., Ren EC; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lye DC; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; National Centre for Infectious Diseases, Singapore, Singapore.; Tan Tock Seng Hospital, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Bertoletti A; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore.; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Young BE; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; National Centre for Infectious Diseases, Singapore, Singapore.; Tan Tock Seng Hospital, Singapore, Singapore., Ng LFP; A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; National Institute of Health Research, Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK.; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Corporate Authors: SCOPE Cohort Study Group
Source: Nature communications [Nat Commun] 2022 Aug 08; Vol. 13 (1), pp. 4615. Date of Electronic Publication: 2022 Aug 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-022-32312-1