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Functional and biological heterogeneity of KRASQ61 mutations.

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Title: Functional and biological heterogeneity of KRASQ61 mutations.
Authors: Huynh MV; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Hobbs GA; Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA., Schaefer A; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Pierobon M; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA 20110, USA., Carey LM; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Diehl JN; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., DeLiberty JM; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Thurman RD; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Cooke AR; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Goodwin CM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Cook JH; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA., Lin L; Department of Molecular and Integrative Physiology, University of Michigan Health System, Ann Arbor, MI 48109, USA., Waters AM; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Rashid NU; Department of Biostatistics, University of North Carolina at Chapel Hill, NC 27955, USA., Petricoin EF 3rd; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA 20110, USA., Campbell SL; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Haigis KM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute, Cambridge, MA 02142, USA.; Harvard Digestive Disease Center, Harvard Medical School, Boston, MA 02115, USA., Simeone DM; Perlmutter Cancer Center, New York University, New York, NY 10016, USA., Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan Health System, Ann Arbor, MI 48109, USA.; Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48198, USA.; University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA., Cox AD; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Der CJ; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Source: Science signaling [Sci Signal] 2022 Aug 09; Vol. 15 (746), pp. eabn2694. Date of Electronic Publication: 2022 Aug 09.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Functional and biological heterogeneity of KRAS<superscript>Q61</superscript> mutations.
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  Data: <searchLink fieldCode="AU" term="%22Huynh+MV%22">Huynh MV</searchLink>; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Hobbs+GA%22">Hobbs GA</searchLink>; Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC 29425, USA.<br /><searchLink fieldCode="AU" term="%22Schaefer+A%22">Schaefer A</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Pierobon+M%22">Pierobon M</searchLink>; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA 20110, USA.<br /><searchLink fieldCode="AU" term="%22Carey+LM%22">Carey LM</searchLink>; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Diehl+JN%22">Diehl JN</searchLink>; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22DeLiberty+JM%22">DeLiberty JM</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Thurman+RD%22">Thurman RD</searchLink>; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Cooke+AR%22">Cooke AR</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Goodwin+CM%22">Goodwin CM</searchLink>; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Cook+JH%22">Cook JH</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Lin+L%22">Lin L</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan Health System, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Waters+AM%22">Waters AM</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Rashid+NU%22">Rashid NU</searchLink>; Department of Biostatistics, University of North Carolina at Chapel Hill, NC 27955, USA.<br /><searchLink fieldCode="AU" term="%22Petricoin+EF+3rd%22">Petricoin EF 3rd</searchLink>; Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA 20110, USA.<br /><searchLink fieldCode="AU" term="%22Campbell+SL%22">Campbell SL</searchLink>; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Haigis+KM%22">Haigis KM</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.; Broad Institute, Cambridge, MA 02142, USA.; Harvard Digestive Disease Center, Harvard Medical School, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Simeone+DM%22">Simeone DM</searchLink>; Perlmutter Cancer Center, New York University, New York, NY 10016, USA.<br /><searchLink fieldCode="AU" term="%22Lyssiotis+CA%22">Lyssiotis CA</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan Health System, Ann Arbor, MI 48109, USA.; Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48198, USA.; University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Cox+AD%22">Cox AD</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Der+CJ%22">Der CJ</searchLink>; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
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  Data: <searchLink fieldCode="JN" term="%22101465400%22">Science signaling</searchLink> [Sci Signal] 2022 Aug 09; Vol. 15 (746), pp. eabn2694. <i>Date of Electronic Publication: </i>2022 Aug 09.
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