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Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.

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Title: Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.
Authors: Liu C; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Jalagam PR; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Feng J; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Wang W; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Raja T; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Sura MR; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Manepalli RKVLP; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Aliphedi BR; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Medavarapu S; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Nair SK; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Muthalagu V; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Natesan R; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Gupta A; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Beno B; Department of Computer-Aided Drug Design & Molecular Analytics, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Panda M; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Ghosh K; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Shukla JK; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Sale H; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Haldar P; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Kalidindi N; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Shah D; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Patel D; Department of Metabolism and Pharmacokinetics, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Mathur A; Department of Discovery Synthesis, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Ellsworth BA; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Cheng D; Department of Cardiovascular and Fibrosis Discovery Biology, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Regueiro-Ren A; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2022 Aug 25; Vol. 65 (16), pp. 11084-11099. Date of Electronic Publication: 2022 Aug 15.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.2c00517