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Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.

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Title: Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.
Authors: Liu C; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Jalagam PR; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Feng J; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Wang W; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Raja T; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Sura MR; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Manepalli RKVLP; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Aliphedi BR; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Medavarapu S; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Nair SK; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Muthalagu V; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Natesan R; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Gupta A; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Beno B; Department of Computer-Aided Drug Design & Molecular Analytics, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Panda M; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Ghosh K; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Shukla JK; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Sale H; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Haldar P; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Kalidindi N; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Shah D; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India., Patel D; Department of Metabolism and Pharmacokinetics, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Mathur A; Department of Discovery Synthesis, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Ellsworth BA; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Cheng D; Department of Cardiovascular and Fibrosis Discovery Biology, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States., Regueiro-Ren A; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2022 Aug 25; Vol. 65 (16), pp. 11084-11099. Date of Electronic Publication: 2022 Aug 15.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification of Monosaccharide Derivatives as Potent, Selective, and Orally Bioavailable Inhibitors of Human and Mouse Galectin-3.
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  Data: <searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Jalagam+PR%22">Jalagam PR</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Feng+J%22">Feng J</searchLink>; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Raja+T%22">Raja T</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Sura+MR%22">Sura MR</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Manepalli+RKVLP%22">Manepalli RKVLP</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Aliphedi+BR%22">Aliphedi BR</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Medavarapu+S%22">Medavarapu S</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Nair+SK%22">Nair SK</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Muthalagu+V%22">Muthalagu V</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Natesan+R%22">Natesan R</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Gupta+A%22">Gupta A</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Beno+B%22">Beno B</searchLink>; Department of Computer-Aided Drug Design & Molecular Analytics, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Panda+M%22">Panda M</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Ghosh+K%22">Ghosh K</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Shukla+JK%22">Shukla JK</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Sale+H%22">Sale H</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Haldar+P%22">Haldar P</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Kalidindi+N%22">Kalidindi N</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Shah+D%22">Shah D</searchLink>; Biocon-Bristol Myers Squibb Research and Development Center, Bangalore 560099, India.<br /><searchLink fieldCode="AU" term="%22Patel+D%22">Patel D</searchLink>; Department of Metabolism and Pharmacokinetics, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Mathur+A%22">Mathur A</searchLink>; Department of Discovery Synthesis, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Ellsworth+BA%22">Ellsworth BA</searchLink>; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Cheng+D%22">Cheng D</searchLink>; Department of Cardiovascular and Fibrosis Discovery Biology, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.<br /><searchLink fieldCode="AU" term="%22Regueiro-Ren+A%22">Regueiro-Ren A</searchLink>; Department of Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2022 Aug 25; Vol. 65 (16), pp. 11084-11099. <i>Date of Electronic Publication: </i>2022 Aug 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.2c00517
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