Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids.
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| Title: | Single-cell analysis of hepatoblastoma identifies tumor signatures that predict chemotherapy susceptibility using patient-specific tumor spheroids. |
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| Authors: | Song H; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, 94143, USA.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, 94143, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94143, USA., Bucher S; Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.; The Liver Center, University of California, San Francisco, San Francisco, CA, 94143, USA., Rosenberg K; The Liver Center, University of California, San Francisco, San Francisco, CA, 94143, USA.; Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA, 94143, USA., Tsui M; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94143, USA.; Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.; The Liver Center, University of California, San Francisco, San Francisco, CA, 94143, USA., Burhan D; Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.; The Liver Center, University of California, San Francisco, San Francisco, CA, 94143, USA., Hoffman D; The Liver Center, University of California, San Francisco, San Francisco, CA, 94143, USA.; Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA, 94143, USA., Cho SJ; Department of Pathology, University of California, San Francisco, San Francisco, CA, 94143, USA.; The Pediatric Liver Center at UCSF Benioff Childrens' Hospitals, San Francisco, CA, 94143, USA., Rangaswami A; The Pediatric Liver Center at UCSF Benioff Childrens' Hospitals, San Francisco, CA, 94143, USA.; Division of Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, 94143, USA., Breese M; Division of Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, 94143, USA., Leung S; Division of Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, 94143, USA., Ventura MVP; Division of Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, 94143, USA., Sweet-Cordero EA; The Pediatric Liver Center at UCSF Benioff Childrens' Hospitals, San Francisco, CA, 94143, USA.; Division of Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, 94143, USA., Huang FW; Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA. franklin.huang@ucsf.edu.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, 94143, USA. franklin.huang@ucsf.edu.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, 94143, USA. franklin.huang@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94143, USA. franklin.huang@ucsf.edu.; Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, CA, 94121, USA. franklin.huang@ucsf.edu.; Chan Zuckerberg Biohub, San Francisco, CA, 94158, USA. franklin.huang@ucsf.edu., Nijagal A; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94143, USA. Amar.Nijagal@ucsf.edu.; The Liver Center, University of California, San Francisco, San Francisco, CA, 94143, USA. Amar.Nijagal@ucsf.edu.; Division of Pediatric Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA, 94143, USA. Amar.Nijagal@ucsf.edu.; The Pediatric Liver Center at UCSF Benioff Childrens' Hospitals, San Francisco, CA, 94143, USA. Amar.Nijagal@ucsf.edu.; Eli and Edythe Broad Center of Regeneration Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA. Amar.Nijagal@ucsf.edu., Wang B; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94143, USA. bruce.wang@ucsf.edu.; Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA. bruce.wang@ucsf.edu.; The Liver Center, University of California, San Francisco, San Francisco, CA, 94143, USA. bruce.wang@ucsf.edu.; The Pediatric Liver Center at UCSF Benioff Childrens' Hospitals, San Francisco, CA, 94143, USA. bruce.wang@ucsf.edu. |
| Source: | Nature communications [Nat Commun] 2022 Aug 25; Vol. 13 (1), pp. 4878. Date of Electronic Publication: 2022 Aug 25. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-022-32473-z |
