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Virtual screening for small-molecule pathway regulators by image-profile matching.

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Title: Virtual screening for small-molecule pathway regulators by image-profile matching.
Authors: Rohban MH; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fuller AM; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Tan C; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Department of Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada., Goldstein JT; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Syangtan D; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Gutnick A; FM Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA, USA., DeVine A; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Nijsure MP; Departments of Orthopaedic Surgery & Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Rigby M; Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Sacher JR; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Corsello SM; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Peppler GB; Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA., Bogaczynska M; Departments of Cell/Tissue Biology and Anatomy, University of California, San Francisco, San Francisco, CA, USA., Boghossian A; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ciotti GE; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hands AT; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mekareeya A; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Doan M; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gale JP; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Derynck R; Departments of Cell/Tissue Biology and Anatomy, University of California, San Francisco, San Francisco, CA, USA., Turbyville T; Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Boerckel JD; Departments of Orthopaedic Surgery & Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Singh S; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kiessling LL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Schwarz TL; FM Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Varelas X; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Wagner FF; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kafri R; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Department of Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada., Eisinger-Mathason TSK; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: karineis@pennmedicine.upenn.edu., Carpenter AE; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: anne@broadinstitute.org.
Source: Cell systems [Cell Syst] 2022 Sep 21; Vol. 13 (9), pp. 724-736.e9. Date of Electronic Publication: 2022 Sep 02.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101656080 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-4720 (Electronic) Linking ISSN: 24054712 NLM ISO Abbreviation: Cell Syst Subsets: MEDLINE
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  Data: Virtual screening for small-molecule pathway regulators by image-profile matching.
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  Data: <searchLink fieldCode="AU" term="%22Rohban+MH%22">Rohban MH</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fuller+AM%22">Fuller AM</searchLink>; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tan+C%22">Tan C</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Department of Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Goldstein+JT%22">Goldstein JT</searchLink>; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Syangtan+D%22">Syangtan D</searchLink>; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gutnick+A%22">Gutnick A</searchLink>; FM Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22DeVine+A%22">DeVine A</searchLink>; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Nijsure+MP%22">Nijsure MP</searchLink>; Departments of Orthopaedic Surgery & Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rigby+M%22">Rigby M</searchLink>; Frederick National Laboratory for Cancer Research, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sacher+JR%22">Sacher JR</searchLink>; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Corsello+SM%22">Corsello SM</searchLink>; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Peppler+GB%22">Peppler GB</searchLink>; Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bogaczynska+M%22">Bogaczynska M</searchLink>; Departments of Cell/Tissue Biology and Anatomy, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Boghossian+A%22">Boghossian A</searchLink>; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ciotti+GE%22">Ciotti GE</searchLink>; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hands+AT%22">Hands AT</searchLink>; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mekareeya+A%22">Mekareeya A</searchLink>; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Doan+M%22">Doan M</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gale+JP%22">Gale JP</searchLink>; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Derynck+R%22">Derynck R</searchLink>; Departments of Cell/Tissue Biology and Anatomy, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Turbyville+T%22">Turbyville T</searchLink>; Frederick National Laboratory for Cancer Research, Frederick, MD, USA.<br /><searchLink fieldCode="AU" term="%22Boerckel+JD%22">Boerckel JD</searchLink>; Departments of Orthopaedic Surgery & Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kiessling+LL%22">Kiessling LL</searchLink>; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Schwarz+TL%22">Schwarz TL</searchLink>; FM Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Varelas+X%22">Varelas X</searchLink>; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wagner+FF%22">Wagner FF</searchLink>; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kafri+R%22">Kafri R</searchLink>; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Department of Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Eisinger-Mathason+TSK%22">Eisinger-Mathason TSK</searchLink>; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: karineis@pennmedicine.upenn.edu.<br /><searchLink fieldCode="AU" term="%22Carpenter+AE%22">Carpenter AE</searchLink>; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: anne@broadinstitute.org.
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  Data: <searchLink fieldCode="JN" term="%22101656080%22">Cell systems</searchLink> [Cell Syst] 2022 Sep 21; Vol. 13 (9), pp. 724-736.e9. <i>Date of Electronic Publication: </i>2022 Sep 02.
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