Virtual screening for small-molecule pathway regulators by image-profile matching.
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| Title: | Virtual screening for small-molecule pathway regulators by image-profile matching. |
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| Authors: | Rohban MH; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fuller AM; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Tan C; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Department of Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada., Goldstein JT; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Syangtan D; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Gutnick A; FM Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA, USA., DeVine A; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Nijsure MP; Departments of Orthopaedic Surgery & Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Rigby M; Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Sacher JR; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Corsello SM; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Peppler GB; Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA., Bogaczynska M; Departments of Cell/Tissue Biology and Anatomy, University of California, San Francisco, San Francisco, CA, USA., Boghossian A; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ciotti GE; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hands AT; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mekareeya A; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Doan M; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gale JP; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Derynck R; Departments of Cell/Tissue Biology and Anatomy, University of California, San Francisco, San Francisco, CA, USA., Turbyville T; Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Boerckel JD; Departments of Orthopaedic Surgery & Bioengineering, University of Pennsylvania, Philadelphia, PA, USA., Singh S; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kiessling LL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Schwarz TL; FM Kirby Neurobiology Center, Boston Children's Hospital, and Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Varelas X; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Wagner FF; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kafri R; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada; Department of Cell Biology, The Hospital for Sick Children, Toronto, ON, Canada., Eisinger-Mathason TSK; Abramson Family Cancer Research Institute, Department of Pathology & Laboratory Medicine, Penn Sarcoma Program, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address: karineis@pennmedicine.upenn.edu., Carpenter AE; Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: anne@broadinstitute.org. |
| Source: | Cell systems [Cell Syst] 2022 Sep 21; Vol. 13 (9), pp. 724-736.e9. Date of Electronic Publication: 2022 Sep 02. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Cell Press Country of Publication: United States NLM ID: 101656080 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-4720 (Electronic) Linking ISSN: 24054712 NLM ISO Abbreviation: Cell Syst Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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