Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression.
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| Title: | Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression. |
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| Authors: | Zhou J; Program of Cardiovascular & Metabolic Disorders, Duke-NUS Medical School Singapore, 8 College Road, Singapore, 169857, Singapore. jin.zhou@duke-nus.edu.sg., Pang J; Program of Cardiovascular & Metabolic Disorders, Duke-NUS Medical School Singapore, 8 College Road, Singapore, 169857, Singapore., Tripathi M; Program of Cardiovascular & Metabolic Disorders, Duke-NUS Medical School Singapore, 8 College Road, Singapore, 169857, Singapore., Ho JP; Program of Cardiovascular & Metabolic Disorders, Duke-NUS Medical School Singapore, 8 College Road, Singapore, 169857, Singapore., Widjaja AA; Program of Cardiovascular & Metabolic Disorders, Duke-NUS Medical School Singapore, 8 College Road, Singapore, 169857, Singapore., Shekeran SG; Program of Cardiovascular & Metabolic Disorders, Duke-NUS Medical School Singapore, 8 College Road, Singapore, 169857, Singapore., Cook SA; Program of Cardiovascular & Metabolic Disorders, Duke-NUS Medical School Singapore, 8 College Road, Singapore, 169857, Singapore.; Medical Research Council, London Institute for Medical Sciences, Imperial College London, London, UK.; National Heart Centre, Singapore, Singapore., Suzuki A; Division of Gastroenterology, Duke University School of Medicine, Durham, NC, USA., Diehl AM; Division of Gastroenterology, Duke University School of Medicine, Durham, NC, USA., Petretto E; Program of Cardiovascular & Metabolic Disorders, Duke-NUS Medical School Singapore, 8 College Road, Singapore, 169857, Singapore.; Medical Research Council, London Institute for Medical Sciences, Imperial College London, London, UK.; Institute for Big Data and Artificial Intelligence in Medicine, School of Science, China Pharmaceutical University, Nanjing, China., Singh BK; Program of Cardiovascular & Metabolic Disorders, Duke-NUS Medical School Singapore, 8 College Road, Singapore, 169857, Singapore., Yen PM; Program of Cardiovascular & Metabolic Disorders, Duke-NUS Medical School Singapore, 8 College Road, Singapore, 169857, Singapore. paul.yen@duke-nus.edu.sg.; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Durham, NC, USA. paul.yen@duke-nus.edu.sg.; Duke University School of Medicine, Durham, NC, USA. paul.yen@duke-nus.edu.sg. |
| Source: | Nature communications [Nat Commun] 2022 Sep 03; Vol. 13 (1), pp. 5202. Date of Electronic Publication: 2022 Sep 03. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, American Recovery and Reinvestment Act |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-022-32788-x |
