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Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical malaria after 2 years' follow-up in children in Burkina Faso: a phase 1/2b randomised controlled trial.

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Title: Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical malaria after 2 years' follow-up in children in Burkina Faso: a phase 1/2b randomised controlled trial.
Authors: Datoo MS; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Natama HM; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Somé A; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Bellamy D; The Jenner Institute Laboratories, University of Oxford, Oxford, UK., Traoré O; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Rouamba T; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Tahita MC; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Ido NFA; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Yameogo P; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Valia D; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Millogo A; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Ouedraogo F; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Soma R; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Sawadogo S; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Sorgho F; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Derra K; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Rouamba E; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Ramos-Lopez F; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Cairns M; International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK., Provstgaard-Morys S; The Jenner Institute Laboratories, University of Oxford, Oxford, UK., Aboagye J; The Jenner Institute Laboratories, University of Oxford, Oxford, UK., Lawrie A; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Roberts R; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK., Valéa I; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Sorgho H; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso., Williams N; Department of Primary Care, University of Oxford, Oxford, UK., Glenn G; Novavax, Gaithersburg, MD, USA., Fries L; Novavax, Gaithersburg, MD, USA., Reimer J; Novavax AB, Uppsala, Sweden., Ewer KJ; The Jenner Institute Laboratories, University of Oxford, Oxford, UK., Shaligram U; Serum Institute of India, Pune, India., Hill AVS; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; The Jenner Institute Laboratories, University of Oxford, Oxford, UK. Electronic address: adrian.hill@ndm.ox.ac.uk., Tinto H; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso. Electronic address: tintoh@crun.bf.
Source: The Lancet. Infectious diseases [Lancet Infect Dis] 2022 Dec; Vol. 22 (12), pp. 1728-1736. Date of Electronic Publication: 2022 Sep 07.
Publication Type: Randomized Controlled Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Efficacy and immunogenicity of R21/Matrix-M vaccine against clinical malaria after 2 years' follow-up in children in Burkina Faso: a phase 1/2b randomised controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Datoo+MS%22">Datoo MS</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Natama+HM%22">Natama HM</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Somé+A%22">Somé A</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Bellamy+D%22">Bellamy D</searchLink>; The Jenner Institute Laboratories, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Traoré+O%22">Traoré O</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Rouamba+T%22">Rouamba T</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Tahita+MC%22">Tahita MC</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Ido+NFA%22">Ido NFA</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Yameogo+P%22">Yameogo P</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Valia+D%22">Valia D</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Millogo+A%22">Millogo A</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Ouedraogo+F%22">Ouedraogo F</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Soma+R%22">Soma R</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Sawadogo+S%22">Sawadogo S</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Sorgho+F%22">Sorgho F</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Derra+K%22">Derra K</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Rouamba+E%22">Rouamba E</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Ramos-Lopez+F%22">Ramos-Lopez F</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Cairns+M%22">Cairns M</searchLink>; International Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK.<br /><searchLink fieldCode="AU" term="%22Provstgaard-Morys+S%22">Provstgaard-Morys S</searchLink>; The Jenner Institute Laboratories, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Aboagye+J%22">Aboagye J</searchLink>; The Jenner Institute Laboratories, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lawrie+A%22">Lawrie A</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Roberts+R%22">Roberts R</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Valéa+I%22">Valéa I</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Sorgho+H%22">Sorgho H</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso.<br /><searchLink fieldCode="AU" term="%22Williams+N%22">Williams N</searchLink>; Department of Primary Care, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Glenn+G%22">Glenn G</searchLink>; Novavax, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Fries+L%22">Fries L</searchLink>; Novavax, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Reimer+J%22">Reimer J</searchLink>; Novavax AB, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Ewer+KJ%22">Ewer KJ</searchLink>; The Jenner Institute Laboratories, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Shaligram+U%22">Shaligram U</searchLink>; Serum Institute of India, Pune, India.<br /><searchLink fieldCode="AU" term="%22Hill+AVS%22">Hill AVS</searchLink>; Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK; The Jenner Institute Laboratories, University of Oxford, Oxford, UK. Electronic address: adrian.hill@ndm.ox.ac.uk.<br /><searchLink fieldCode="AU" term="%22Tinto+H%22">Tinto H</searchLink>; Unité de Recherche Clinique de Nanoro, Institut de Recherche en Sciences de la Santé, Nanoro, Burkina Faso. Electronic address: tintoh@crun.bf.
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  Data: <searchLink fieldCode="JN" term="%22101130150%22">The Lancet. Infectious diseases</searchLink> [Lancet Infect Dis] 2022 Dec; Vol. 22 (12), pp. 1728-1736. <i>Date of Electronic Publication: </i>2022 Sep 07.
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