Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease.
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| Title: | Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease. |
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| Authors: | Mishra N; Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany., Aden K; Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany., Blase JI; Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany., Baran N; Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany., Bordoni D; Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany., Tran F; Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany., Conrad C; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany., Avalos D; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva, Geneva, Switzerland., Jaeckel C; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany., Scherer M; Department of Genetics, University of Saarland, Saarbrücken, Germany.; Present address: Department of Bioinformatics and Genomics, Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, 08003, Barcelona, Spain., Sørensen SB; The Molecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Overgaard SH; The Molecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.; Section for Biostatistics and Evidence-Based Research, the Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Schulte B; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany., Nikolaus S; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany., Rey G; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva, Geneva, Switzerland., Gasparoni G; Department of Genetics, University of Saarland, Saarbrücken, Germany., Lyons PA; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, CB 0AW, UK.; Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK., Schultze JL; Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE), and University of Bonn, Bonn, Germany., Walter J; Department of Genetics, University of Saarland, Saarbrücken, Germany., Andersen V; The Molecular Diagnostics and Clinical Research Unit, University Hospital of Southern Denmark, Aabenraa, Denmark.; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Dermitzakis ET; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva, Geneva, Switzerland., Schreiber S; Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany. s.schreiber@mucosa.de.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany. s.schreiber@mucosa.de., Rosenstiel P; Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel and University Medical Center Schleswig-Holstein, Kiel, Germany. p.rosenstiel@mucosa.de.; Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany. p.rosenstiel@mucosa.de. |
| Corporate Authors: | SYSCID Consortium |
| Source: | Genome medicine [Genome Med] 2022 Sep 24; Vol. 14 (1), pp. 110. Date of Electronic Publication: 2022 Sep 24. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1756-994X |
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| DOI: | 10.1186/s13073-022-01112-z |
