Quinazoline-based human phosphodiesterase 5 inhibitors exhibited a selective vasorelaxant effect on rat isolated pulmonary arteries involving NO-sGC-cGMP pathway and calcium inhibitory effects.
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| Title: | Quinazoline-based human phosphodiesterase 5 inhibitors exhibited a selective vasorelaxant effect on rat isolated pulmonary arteries involving NO-sGC-cGMP pathway and calcium inhibitory effects. |
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| Authors: | Chatturong U; Department of Physiology, Faculty of Medical Science and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand; PEPITE EA4267, Université Bourgogne Franche-Comté, Besançon 25030, France., Martin H; PEPITE EA4267, Université Bourgogne Franche-Comté, Besançon 25030, France., Totoson P; PEPITE EA4267, Université Bourgogne Franche-Comté, Besançon 25030, France., Ingkaninan K; Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand., Temkitthawon P; Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand., Sermsenaphorn S; Department of Biomedical Engineering, Faculty of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok 10520, Thailand., Somarin T; Department of Biomedical Engineering, Faculty of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok 10520, Thailand., Konsue A; Department of Biomedical Engineering, Faculty of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok 10520, Thailand., Gleeson MP; Department of Biomedical Engineering, Faculty of Engineering, King Mongkut's Institute of Technology, Ladkrabang, Bangkok 10520, Thailand., Demougeot C; PEPITE EA4267, Université Bourgogne Franche-Comté, Besançon 25030, France., Chootip K; Department of Physiology, Faculty of Medical Science and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand. Electronic address: krongkarnc@nu.ac.th. |
| Source: | Vascular pharmacology [Vascul Pharmacol] 2022 Dec; Vol. 147, pp. 107111. Date of Electronic Publication: 2022 Sep 24. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3649 (Electronic) Linking ISSN: 15371891 NLM ISO Abbreviation: Vascul Pharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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