Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas.
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| Title: | Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas. |
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| Authors: | Goschzik T; Department of Neuropathology and DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Venusberg-Campus 1, D-53127, Bonn, Germany., Mynarek M; Department of Pediatric Hematology/Oncology, University Clinics Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Doerner E; Department of Neuropathology and DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Venusberg-Campus 1, D-53127, Bonn, Germany., Schenk A; Institute of Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Bonn, Germany., Spier I; Institute of Human Genetics and Center for Hereditary Tumor Syndromes, Medical Faculty, University of Bonn, Bonn, Germany., Warmuth-Metz M; Institute of Diagnostic and Interventional Neuroradiology, University Hospital Wuerzburg, Würzburg, Germany., Bison B; Department of Neuroradiology, University Hospital, Augsburg, Germany., Obrecht D; Department of Pediatric Hematology/Oncology, University Clinics Hamburg-Eppendorf, Hamburg, Germany., Struve N; Department of Radiotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kortmann RD; Department of Radiation Oncology, University of Leipzig, Leipzig, Germany., Schmid M; Institute of Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Bonn, Germany., Aretz S; Institute of Human Genetics and Center for Hereditary Tumor Syndromes, Medical Faculty, University of Bonn, Bonn, Germany., Rutkowski S; Department of Pediatric Hematology/Oncology, University Clinics Hamburg-Eppendorf, Hamburg, Germany., Pietsch T; Department of Neuropathology and DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Venusberg-Campus 1, D-53127, Bonn, Germany. t.pietsch@uni-bonn.de. |
| Source: | Acta neuropathologica [Acta Neuropathol] 2022 Dec; Vol. 144 (6), pp. 1143-1156. Date of Electronic Publication: 2022 Oct 01. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1432-0533 |
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| DOI: | 10.1007/s00401-022-02505-5 |
