Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy.
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| Title: | Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy. |
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| Authors: | Isser A; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Silver AB; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21287, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Pruitt HC; Department of Chemical and Biomolecular Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA.; Institute for NanoBioTechnology, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA., Mass M; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Elias EH; Department of Biology, Johns Hopkins University Krieger School of Arts and Sciences, Baltimore, MD, 21287, USA., Aihara G; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Kang SS; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Bachmann N; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Chen YY; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Leonard EK; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Bieler JG; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Chaisawangwong W; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Choy J; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Institute for NanoBioTechnology, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA.; Department of Materials Science and Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA., Shannon SR; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Gerecht S; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA.; Institute for NanoBioTechnology, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA.; Department of Materials Science and Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Weber JS; Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, 10016, USA., Spangler JB; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA.; Department of Materials Science and Engineering, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, 21287, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA., Schneck JP; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. jschnec1@jhmi.edu.; Johns Hopkins Translational ImmunoEngineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. jschnec1@jhmi.edu.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. jschnec1@jhmi.edu.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. jschnec1@jhmi.edu.; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. jschnec1@jhmi.edu. |
| Source: | Nature communications [Nat Commun] 2022 Oct 14; Vol. 13 (1), pp. 6086. Date of Electronic Publication: 2022 Oct 14. |
| Publication Type: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-022-33597-y |
