Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial.

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Title: Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial.
Authors: Spinazzi EF; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Argenziano MG; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Upadhyayula PS; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Banu MA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Neira JA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Higgins DMO; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Wu PB; Department of Neurological Surgery, UCLA Geffen School of Medicine, Los Angeles, CA, USA., Pereira B; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Mahajan A; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Humala N; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Al-Dalahmah O; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Zhao W; Department of System Biology, Columbia University Irving Medical Center, New York, NY, USA., Save AV; Department of Neurological Surgery, NYU Grossman School of Medicine, New York, NY, USA., Gill BJA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Boyett DM; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Marie T; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Furnari JL; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Sudhakar TD; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Stopka SA; Department of Neurosurgery and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Regan MS; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Catania V; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Good L; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Zacharoulis S; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA., Behl M; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA., Petridis P; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Jambawalikar S; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA., Mintz A; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA., Lignelli A; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA., Agar NYR; Department of Neurosurgery and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute Boston, MA, USA., Sims PA; Department of System Biology, Columbia University Irving Medical Center, New York, NY, USA., Welch MR; Division of Neuro-Oncology, Department of Neurology and the Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY, USA., Lassman AB; Division of Neuro-Oncology, Department of Neurology and the Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY, USA., Iwamoto FM; Division of Neuro-Oncology, Department of Neurology and the Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY, USA., D'Amico RS; Department of Neurosurgery, Lenox Hill Hospital, New York, NY, USA., Grinband J; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA., Canoll P; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Bruce JN; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: jnb2@cumc.columbia.edu.
Source: The Lancet. Oncology [Lancet Oncol] 2022 Nov; Vol. 23 (11), pp. 1409-1418. Date of Electronic Publication: 2022 Oct 13.
Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-5488
DOI:10.1016/S1470-2045(22)00599-X