Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial.
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| Title: | Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial. |
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| Authors: | Spinazzi EF; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Argenziano MG; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Upadhyayula PS; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Banu MA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Neira JA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Higgins DMO; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Wu PB; Department of Neurological Surgery, UCLA Geffen School of Medicine, Los Angeles, CA, USA., Pereira B; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Mahajan A; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Humala N; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Al-Dalahmah O; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Zhao W; Department of System Biology, Columbia University Irving Medical Center, New York, NY, USA., Save AV; Department of Neurological Surgery, NYU Grossman School of Medicine, New York, NY, USA., Gill BJA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Boyett DM; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Marie T; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Furnari JL; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Sudhakar TD; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Stopka SA; Department of Neurosurgery and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Regan MS; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Catania V; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Good L; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Zacharoulis S; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA., Behl M; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA., Petridis P; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA., Jambawalikar S; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA., Mintz A; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA., Lignelli A; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA., Agar NYR; Department of Neurosurgery and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute Boston, MA, USA., Sims PA; Department of System Biology, Columbia University Irving Medical Center, New York, NY, USA., Welch MR; Division of Neuro-Oncology, Department of Neurology and the Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY, USA., Lassman AB; Division of Neuro-Oncology, Department of Neurology and the Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY, USA., Iwamoto FM; Division of Neuro-Oncology, Department of Neurology and the Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY, USA., D'Amico RS; Department of Neurosurgery, Lenox Hill Hospital, New York, NY, USA., Grinband J; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA., Canoll P; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA., Bruce JN; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: jnb2@cumc.columbia.edu. |
| Source: | The Lancet. Oncology [Lancet Oncol] 2022 Nov; Vol. 23 (11), pp. 1409-1418. Date of Electronic Publication: 2022 Oct 13. |
| Publication Type: | Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 36243020 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Spinazzi+EF%22">Spinazzi EF</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Argenziano+MG%22">Argenziano MG</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Upadhyayula+PS%22">Upadhyayula PS</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Banu+MA%22">Banu MA</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Neira+JA%22">Neira JA</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Higgins+DMO%22">Higgins DMO</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Wu+PB%22">Wu PB</searchLink>; Department of Neurological Surgery, UCLA Geffen School of Medicine, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pereira+B%22">Pereira B</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mahajan+A%22">Mahajan A</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Humala+N%22">Humala N</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Al-Dalahmah+O%22">Al-Dalahmah O</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; Department of System Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Save+AV%22">Save AV</searchLink>; Department of Neurological Surgery, NYU Grossman School of Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gill+BJA%22">Gill BJA</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Boyett+DM%22">Boyett DM</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Marie+T%22">Marie T</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Furnari+JL%22">Furnari JL</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sudhakar+TD%22">Sudhakar TD</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Stopka+SA%22">Stopka SA</searchLink>; Department of Neurosurgery and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Regan+MS%22">Regan MS</searchLink>; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Catania+V%22">Catania V</searchLink>; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Good+L%22">Good L</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zacharoulis+S%22">Zacharoulis S</searchLink>; Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Behl+M%22">Behl M</searchLink>; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Petridis+P%22">Petridis P</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Jambawalikar+S%22">Jambawalikar S</searchLink>; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mintz+A%22">Mintz A</searchLink>; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lignelli+A%22">Lignelli A</searchLink>; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Agar+NYR%22">Agar NYR</searchLink>; Department of Neurosurgery and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sims+PA%22">Sims PA</searchLink>; Department of System Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Welch+MR%22">Welch MR</searchLink>; Division of Neuro-Oncology, Department of Neurology and the Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lassman+AB%22">Lassman AB</searchLink>; Division of Neuro-Oncology, Department of Neurology and the Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Iwamoto+FM%22">Iwamoto FM</searchLink>; Division of Neuro-Oncology, Department of Neurology and the Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons and New York-Presbyterian Hospital, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22D'Amico+RS%22">D'Amico RS</searchLink>; Department of Neurosurgery, Lenox Hill Hospital, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Grinband+J%22">Grinband J</searchLink>; Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA; Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Canoll+P%22">Canoll P</searchLink>; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Bruce+JN%22">Bruce JN</searchLink>; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY, USA. Electronic address: jnb2@cumc.columbia.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100957246%22">The Lancet. Oncology</searchLink> [Lancet Oncol] 2022 Nov; Vol. 23 (11), pp. 1409-1418. <i>Date of Electronic Publication: </i>2022 Oct 13. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lancet+Pub%2E+Group%22">Lancet Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100957246 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-5488 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214702045%22">14702045 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Oncol <i>Subsets: </i>MEDLINE |
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