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Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.

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Bibliographic Details
Title: Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
Authors: Futatsugi K; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Cabral S; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Kung DW; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Huard K; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Lee E; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Boehm M; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Bauman J; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Clark RW; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Coffey SB; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Crowley C; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Dechert-Schmitt AM; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Dowling MS; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Dullea R; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Gosset JR; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Kalgutkar AS; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Kou K; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Li Q; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Lian Y; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Loria PM; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Londregan AT; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Niosi M; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Orozco C; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Pettersen JC; Pfizer Inc. Drug Safety R&D, Eastern Point Road, Groton, Connecticut 06340, United States., Pfefferkorn JA; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Polivkova J; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Ross TT; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Sharma R; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Stock IA; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Tesz G; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Wisniewska H; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Goodwin B; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Price DA; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2022 Nov 24; Vol. 65 (22), pp. 15000-15013. Date of Electronic Publication: 2022 Nov 02.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.2c01200