Comparative effects of human-equivalent low, moderate, and high dose oral prednisone intake on autoimmunity and glucocorticoid-related toxicity in a murine model of environmental-triggered lupus.

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Title: Comparative effects of human-equivalent low, moderate, and high dose oral prednisone intake on autoimmunity and glucocorticoid-related toxicity in a murine model of environmental-triggered lupus.
Authors: Heine LK; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United States.; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States., Benninghoff AD; Department of Animal, Dairy and Veterinary Sciences, School of Veterinary Medicine, Utah State University, Logan, UT, United States., Ross EA; Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, United States., Rajasinghe LD; Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, United States., Wagner JG; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, United States., Lewandowski RP; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, United States., Richardson AL; Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, United States., Li QZ; Department of Immunology and Internal Medicine, Institute fo Innovations in Medical Technology (IIMT) Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX, United States., Buchweitz JP; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, United States.; Toxicology Section, Michigan State University Veterinary Diagnostic Laboratory, Lansing, MI, United States., Zyskowski J; Toxicology Section, Michigan State University Veterinary Diagnostic Laboratory, Lansing, MI, United States., Tindle AN; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, United States., Skedel AE; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, United States., Chargo NJ; Department of Physiology, Michigan State University, East Lansing, MI, United States., McCabe LR; Department of Physiology, Michigan State University, East Lansing, MI, United States., Harkema JR; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United States.; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.; Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, United States., Pestka JJ; Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, United States.; Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, United States.; Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, United States.
Source: Frontiers in immunology [Front Immunol] 2022 Oct 19; Vol. 13, pp. 972108. Date of Electronic Publication: 2022 Oct 19 (Print Publication: 2022).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1664-3224
DOI:10.3389/fimmu.2022.972108