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Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies.

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Title: Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies.
Authors: Goodman DB; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA.; Gladstone UCSF Institute for Genetic Immunology, San Francisco, CA 94107, USA.; School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA., Azimi CS; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA.; Gladstone UCSF Institute for Genetic Immunology, San Francisco, CA 94107, USA., Kearns K; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA., Talbot A; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA.; Gladstone UCSF Institute for Genetic Immunology, San Francisco, CA 94107, USA.; INSERM U976, Saint Louis Research Institute, Paris City University, Paris, France., Garakani K; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA., Garcia J; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA., Patel N; School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.; Department of Oral and Maxillofacial Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA., Hwang B; Institute for Human Genetics (IHG), University of California, San Francisco, San Francisco, CA 94143, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul 03722, Korea., Lee D; Institute for Human Genetics (IHG), University of California, San Francisco, San Francisco, CA 94143, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA., Park E; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA., Vykunta VS; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA.; Gladstone UCSF Institute for Genetic Immunology, San Francisco, CA 94107, USA.; School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA., Shy BR; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA.; Gladstone UCSF Institute for Genetic Immunology, San Francisco, CA 94107, USA.; School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA., Ye CJ; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA 94143, USA.; Institute for Human Genetics (IHG), University of California, San Francisco, San Francisco, CA 94143, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143, USA., Eyquem J; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA.; Gladstone UCSF Institute for Genetic Immunology, San Francisco, CA 94107, USA., Marson A; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA.; Gladstone UCSF Institute for Genetic Immunology, San Francisco, CA 94107, USA.; School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.; Institute for Human Genetics (IHG), University of California, San Francisco, San Francisco, CA 94143, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Bluestone JA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.; Sonoma Biotherapeutics, South San Francisco, CA 94080, USA., Roybal KT; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.; Parker Institute for Cancer Immunotherapy, San Francisco, CA 94143, USA.; Gladstone UCSF Institute for Genetic Immunology, San Francisco, CA 94107, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.; UCSF Cell Design Institute, San Francisco, CA 94158, USA.
Source: Science translational medicine [Sci Transl Med] 2022 Nov 09; Vol. 14 (670), pp. eabm1463. Date of Electronic Publication: 2022 Nov 09.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.abm1463