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SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines.

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Title: SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines.
Authors: Bowen JE; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Park YJ; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA., Stewart C; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Brown JT; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Sharkey WK; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Walls AC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA., Joshi A; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Sprouse KR; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., McCallum M; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Tortorici MA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Franko NM; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA., Logue JK; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA., Mazzitelli IG; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Facultad de Medicina, Buenos Aires C1121ABG, Argentina., Nguyen AW; McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA., Silva RP; McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA., Huang Y; McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA., Low JS; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Jerak J; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Tiles SW; Center for Emerging and Re-emerging Infectious Diseases, Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA., Ahmed K; Departments of Paediatrics and Child Health and Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan., Shariq A; Departments of Paediatrics and Child Health and Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan., Dan JM; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA., Zhang Z; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA., Snell G; Vir Biotechnology, San Francisco, CA 94158, USA., Posavad CM; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Iqbal NT; Departments of Paediatrics and Child Health and Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan., Geffner J; Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Facultad de Medicina, Buenos Aires C1121ABG, Argentina., Bandera A; Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy., Gori A; Infectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy., Sallusto F; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Maynard JA; McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA., Crotty S; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, CA UC92037, USA., Van Voorhis WC; Center for Emerging and Re-emerging Infectious Diseases, Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA., Simmerling C; Department of Chemistry, Stony Brook University, Stony Brook, NY 11794, USA.; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794, USA., Grifantini R; INGM, Istituto Nazionale Genetica Molecolare 'Romeo ed Enrica Invernizzi,' 20122 Milan, Italy., Chu HY; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98195, USA., Corti D; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
Source: Science immunology [Sci Immunol] 2022 Dec 23; Vol. 7 (78), pp. eadf1421. Date of Electronic Publication: 2022 Dec 23.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE
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  Data: SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines.
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