An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma.

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Title: An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma.
Authors: Darawshi O; Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel., Muz B; Department of Radiation Oncology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Naamat SG; Department of Genetics, The Hebrew University of Jerusalem, Jerusalem, Israel., Praveen B; Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel., Mahameed M; Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel., Goldberg K; Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel., Dipta P; Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel., Shmuel M; Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel., Forno F; Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel., Boukeileh S; Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel., Pahima H; Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel., Hermann J; German Cancer Research Center (DKFZ), Heidelberg, Germany., Raab MS; Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany., Poos AM; Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany., Weinhold N; Department of Internal Medicine V, University Hospital Heidelberg, Heidelberg, Germany., Rosenbluh C; Department of Genetics, The Hebrew University of Jerusalem, Jerusalem, Israel., Gatt ME; Hematology Dept. Hadassah Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel., Palm W; German Cancer Research Center (DKFZ), Heidelberg, Germany., Azab AK; Department Biomedical Engineering, UT Southwestern, Dallas, TX, USA., Tirosh B; Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel. boazt@ekmd.huji.ac.il.; Case Western Reserve University, Department of Biochemistry, Cleveland, OH, USA. boazt@ekmd.huji.ac.il.
Source: Cell death & disease [Cell Death Dis] 2022 Nov 18; Vol. 13 (11), pp. 969. Date of Electronic Publication: 2022 Nov 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-4889
DOI:10.1038/s41419-022-05421-4