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Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

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Title: Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
Authors: Murtaza N; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Krembil Research Institute, University Health Network, Toronto, ON, Canada., Cheng AA; Krembil Research Institute, University Health Network, Toronto, ON, Canada., Brown CO; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Krembil Research Institute, University Health Network, Toronto, ON, Canada., Meka DP; Center for Molecular Neurobiology Hamburg (ZMNH), Research Group Neuronal Development, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Hong S; Center for Molecular Neurobiology Hamburg (ZMNH), Research Group Neuronal Development, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Uy JA; Krembil Research Institute, University Health Network, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., El-Hajjar J; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Pipko N; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Unda BK; Krembil Research Institute, University Health Network, Toronto, ON, Canada., Schwanke B; Center for Molecular Neurobiology Hamburg (ZMNH), Research Group Neuronal Development, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Xing S; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Thiruvahindrapuram B; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada., Engchuan W; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada., Trost B; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada., Deneault E; Centre for Biologics Evaluation, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada., Calderon de Anda F; Center for Molecular Neurobiology Hamburg (ZMNH), Research Group Neuronal Development, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany., Doble BW; Department of Paediatrics, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada., Ellis J; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Anagnostou E; Department of Neurology, The Hospital for Sick Children, Toronto, ON, Canada; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada., Bader GD; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Scherer SW; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Lu Y; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada., Singh KK; Krembil Research Institute, University Health Network, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: karun.singh@uhnresearch.ca.
Source: Cell reports [Cell Rep] 2022 Nov 22; Vol. 41 (8), pp. 111678.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.
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  Data: <searchLink fieldCode="AU" term="%22Murtaza+N%22">Murtaza N</searchLink>; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Krembil Research Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Cheng+AA%22">Cheng AA</searchLink>; Krembil Research Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Brown+CO%22">Brown CO</searchLink>; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada; Krembil Research Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Meka+DP%22">Meka DP</searchLink>; Center for Molecular Neurobiology Hamburg (ZMNH), Research Group Neuronal Development, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hong+S%22">Hong S</searchLink>; Center for Molecular Neurobiology Hamburg (ZMNH), Research Group Neuronal Development, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Uy+JA%22">Uy JA</searchLink>; Krembil Research Institute, University Health Network, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22El-Hajjar+J%22">El-Hajjar J</searchLink>; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Pipko+N%22">Pipko N</searchLink>; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Unda+BK%22">Unda BK</searchLink>; Krembil Research Institute, University Health Network, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Schwanke+B%22">Schwanke B</searchLink>; Center for Molecular Neurobiology Hamburg (ZMNH), Research Group Neuronal Development, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Xing+S%22">Xing S</searchLink>; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Thiruvahindrapuram+B%22">Thiruvahindrapuram B</searchLink>; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Engchuan+W%22">Engchuan W</searchLink>; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Trost+B%22">Trost B</searchLink>; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Deneault+E%22">Deneault E</searchLink>; Centre for Biologics Evaluation, Biologic and Radiopharmaceutical Drugs Directorate, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Calderon+de+Anda+F%22">Calderon de Anda F</searchLink>; Center for Molecular Neurobiology Hamburg (ZMNH), Research Group Neuronal Development, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Doble+BW%22">Doble BW</searchLink>; Department of Paediatrics, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada.<br /><searchLink fieldCode="AU" term="%22Ellis+J%22">Ellis J</searchLink>; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Anagnostou+E%22">Anagnostou E</searchLink>; Department of Neurology, The Hospital for Sick Children, Toronto, ON, Canada; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bader+GD%22">Bader GD</searchLink>; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Scherer+SW%22">Scherer SW</searchLink>; The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ON, Canada; Department of Molecular Genetics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Lu+Y%22">Lu Y</searchLink>; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Singh+KK%22">Singh KK</searchLink>; Krembil Research Institute, University Health Network, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: karun.singh@uhnresearch.ca.
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