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Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features.

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Title: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features.
Authors: Flanagan DJ; Cancer Research UK Beatson Institute, Glasgow, UK. dustin.flanagan@monash.edu.; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Australia. dustin.flanagan@monash.edu.; Cancer Program, Biomedicine Discovery Institute, Monash University, Melbourne, Australia. dustin.flanagan@monash.edu., Amirkhah R; The Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Vincent DF; Cancer Research UK Beatson Institute, Glasgow, UK., Gunduz N; Cancer Research UK Beatson Institute, Glasgow, UK., Gentaz P; Cancer Research UK Beatson Institute, Glasgow, UK., Cammareri P; Cancer Research UK Beatson Institute, Glasgow, UK., McCooey AJ; The Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., McCorry AMB; The Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Fisher NC; The Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Davis HL; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Ridgway RA; Cancer Research UK Beatson Institute, Glasgow, UK., Lohuis J; Department of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Leach JDG; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Jackstadt R; Cancer Research UK Beatson Institute, Glasgow, UK.; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH) and Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany., Gilroy K; Cancer Research UK Beatson Institute, Glasgow, UK., Mariella E; Department of Oncology, University of Torino, Candiolo, Torino, Italy., Nixon C; Cancer Research UK Beatson Institute, Glasgow, UK., Clark W; Cancer Research UK Beatson Institute, Glasgow, UK., Hedley A; Cancer Research UK Beatson Institute, Glasgow, UK.; University of Newcastle upon Tyne, Newcastle, UK., Markert EK; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Strathdee D; Cancer Research UK Beatson Institute, Glasgow, UK., Bartholin L; INSERM Centre de Recherche en Cancérologie de Lyon, Lyon, France., Redmond KL; The Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Kerr EM; The Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Longley DB; The Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Ginty F; GE Global Research Center, Niskayuna, NY, USA., Cho S; GE Global Research Center, Niskayuna, NY, USA., Coleman HG; The Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.; Centre for Public Health, Queen's University Belfast, Belfast, UK., Loughrey MB; The Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK.; Centre for Public Health, Queen's University Belfast, Belfast, UK.; Department of Cellular Pathology, Belfast Health and Social Care Trust, Belfast, UK., Bardelli A; Department of Oncology, University of Torino, Candiolo, Torino, Italy., Maughan TS; CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK., Campbell AD; Cancer Research UK Beatson Institute, Glasgow, UK., Lawler M; The Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Leedham SJ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Barry ST; Bioscience, Oncology R&D, AstraZeneca, Cambridge, UK., Inman GJ; Cancer Research UK Beatson Institute, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., van Rheenen J; Department of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Dunne PD; Cancer Research UK Beatson Institute, Glasgow, UK.; The Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, UK., Sansom OJ; Cancer Research UK Beatson Institute, Glasgow, UK. o.sansom@beatson.gla.ac.uk.; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. o.sansom@beatson.gla.ac.uk.
Source: Nature communications [Nat Commun] 2022 Dec 07; Vol. 13 (1), pp. 7551. Date of Electronic Publication: 2022 Dec 07.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-022-35134-3