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Apilimod enhances specific productivity in recombinant CHO cells through cell cycle arrest and mediation of autophagy.

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Title: Apilimod enhances specific productivity in recombinant CHO cells through cell cycle arrest and mediation of autophagy.
Authors: Lu JT; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China., Xiao MK; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China.; School of Public Health, Xinxiang Medical University, Xinxiang, Henan, China., Feng YY; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China., Wang XY; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Qiu LL; School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Chai YR; Department of Histology and Embryology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China., Wang TY; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, China., Jia YL; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China.
Source: Biotechnology journal [Biotechnol J] 2023 Feb; Vol. 18 (2), pp. e2200147. Date of Electronic Publication: 2022 Dec 14.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 101265833 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7314 (Electronic) Linking ISSN: 18606768 NLM ISO Abbreviation: Biotechnol J Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Apilimod enhances specific productivity in recombinant CHO cells through cell cycle arrest and mediation of autophagy.
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  Data: <searchLink fieldCode="AU" term="%22Lu+JT%22">Lu JT</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China.<br /><searchLink fieldCode="AU" term="%22Xiao+MK%22">Xiao MK</searchLink>; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China.; School of Public Health, Xinxiang Medical University, Xinxiang, Henan, China.<br /><searchLink fieldCode="AU" term="%22Feng+YY%22">Feng YY</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China.<br /><searchLink fieldCode="AU" term="%22Wang+XY%22">Wang XY</searchLink>; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, China.<br /><searchLink fieldCode="AU" term="%22Qiu+LL%22">Qiu LL</searchLink>; School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, China.<br /><searchLink fieldCode="AU" term="%22Chai+YR%22">Chai YR</searchLink>; Department of Histology and Embryology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.<br /><searchLink fieldCode="AU" term="%22Wang+TY%22">Wang TY</searchLink>; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China.; School of Basic Medicine, Xinxiang Medical University, Xinxiang, Henan, China.<br /><searchLink fieldCode="AU" term="%22Jia+YL%22">Jia YL</searchLink>; School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China.; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, Xinxiang Medical University, Xinxiang, Henan, China.; Henan Engineering Research Center for Biopharmaceutical Innovation, Xinxiang Medical University, Xinxiang, Henan, China.
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  Data: <searchLink fieldCode="JN" term="%22101265833%22">Biotechnology journal</searchLink> [Biotechnol J] 2023 Feb; Vol. 18 (2), pp. e2200147. <i>Date of Electronic Publication: </i>2022 Dec 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wiley-VCH+Verlag%22">Wiley-VCH Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101265833 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1860-7314 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2218606768%22">18606768 </searchLink><i>NLM ISO Abbreviation: </i>Biotechnol J <i>Subsets: </i>MEDLINE
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        Value: 10.1002/biot.202200147
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              Text: 2023 Feb
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