Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells.

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Title:	Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells.
Authors:	Comez D; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, United Kingdom., Glenn J; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, United Kingdom., Anbuhl SM; Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS) Vrije Universiteit (VU), Amsterdam, Netherlands.; QVQ Holding BV, Utrecht, Netherlands., Heukers R; Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS) Vrije Universiteit (VU), Amsterdam, Netherlands.; QVQ Holding BV, Utrecht, Netherlands., Smit MJ; Division of Medicinal Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS) Vrije Universiteit (VU), Amsterdam, Netherlands., Hill SJ; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, United Kingdom., Kilpatrick LE; Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, The Midlands Nottingham, Nottingham, United Kingdom.; Division of Bimolecular Science and Medicinal Chemistry, Biodiscovery Institute, School of Pharmacy, University of Nottingham, Nottingham, United Kingdom.
Source:	Frontiers in immunology [Front Immunol] 2022 Nov 23; Vol. 13, pp. 1006718. Date of Electronic Publication: 2022 Nov 23 (Print Publication: 2022).
Publication Type:	Journal Article
Journal Info:	Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database:	MEDLINE Ultimate

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ISSN:	1664-3224
DOI:	10.3389/fimmu.2022.1006718