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Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

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Title: Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
Authors: Londregan AT; Pfizer Medicine Design, Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Aitmakhanova K; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K., Bennett J; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K., Byrnes LJ; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Canterbury DP; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Cheng X; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Christott T; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K., Clemens J; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Coffey SB; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Dias JM; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Dowling MS; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Farnie G; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K., Fedorov O; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K., Fennell KF; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Gamble V; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K., Gileadi C; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K., Giroud C; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K., Harris MR; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Hollingshead BD; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Huber K; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K., Korczynska M; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Lapham K; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Loria PM; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Narayanan A; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Owen DR; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Raux B; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K., Sahasrabudhe PV; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Ruggeri RB; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Sáez LD; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K., Stock IA; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Thuma BA; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Tsai A; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Varghese AE; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2023 Jan 12; Vol. 66 (1), pp. 460-472. Date of Electronic Publication: 2022 Dec 23.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K.<br /><searchLink fieldCode="AU" term="%22Clemens+J%22">Clemens J</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Coffey+SB%22">Coffey SB</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Dias+JM%22">Dias JM</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Dowling+MS%22">Dowling MS</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Farnie+G%22">Farnie G</searchLink>; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K.<br /><searchLink fieldCode="AU" term="%22Fedorov+O%22">Fedorov O</searchLink>; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K.<br /><searchLink fieldCode="AU" term="%22Fennell+KF%22">Fennell KF</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Gamble+V%22">Gamble V</searchLink>; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K.<br /><searchLink fieldCode="AU" term="%22Gileadi+C%22">Gileadi C</searchLink>; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K.<br /><searchLink fieldCode="AU" term="%22Giroud+C%22">Giroud C</searchLink>; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K.<br /><searchLink fieldCode="AU" term="%22Harris+MR%22">Harris MR</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Hollingshead+BD%22">Hollingshead BD</searchLink>; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Huber+K%22">Huber K</searchLink>; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K.<br /><searchLink fieldCode="AU" term="%22Korczynska+M%22">Korczynska M</searchLink>; 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Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Sáez+LD%22">Sáez LD</searchLink>; Centre for Medicines Discovery, NDM, University of Oxford, Oxford OX3 7DQ, U.K.<br /><searchLink fieldCode="AU" term="%22Stock+IA%22">Stock IA</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Thuma+BA%22">Thuma BA</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Tsai+A%22">Tsai A</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Varghese+AE%22">Varghese AE</searchLink>; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2023 Jan 12; Vol. 66 (1), pp. 460-472. <i>Date of Electronic Publication: </i>2022 Dec 23.
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