A stem cell epigenome is associated with primary nonresponse to CD19 CAR T cells in pediatric acute lymphoblastic leukemia.

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Title: A stem cell epigenome is associated with primary nonresponse to CD19 CAR T cells in pediatric acute lymphoblastic leukemia.
Authors: Masih KE; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.; Cancer Research United Kingdom Cambridge Institute, University of Cambridge, Cambridge, England.; Medical Scientist Training Program, University of Miami Leonard M. Miller School of Medicine, Miami, FL., Gardner RA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA.; Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA.; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA., Chou HC; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD., Abdelmaksoud A; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD., Song YK; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD., Mariani L; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Gangalapudi V; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD., Gryder BE; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH., Wilson AL; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA., Adebola SO; Immunodynamics Group, Cancer and Inflammation Program, Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD., Stanton BZ; Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, Columbus, OH., Wang C; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD., Milewski D; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD., Kim YY; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD., Tian M; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD., Cheuk AT; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD., Wen X; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD., Zhang Y; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA., Altan-Bonnet G; Immunodynamics Group, Cancer and Inflammation Program, Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD., Kelly MC; Center for Cancer Research Single Cell Analysis Facility, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Bethesda, MD., Wei JS; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD., Bulyk ML; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Jensen MC; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA.; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA., Orentas RJ; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA.; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, WA., Khan J; Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Source: Blood advances [Blood Adv] 2023 Aug 08; Vol. 7 (15), pp. 4218-4232.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2473-9537
DOI:10.1182/bloodadvances.2022008977