Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes.

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Title: Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes.
Authors: Sparbier CE; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Gillespie A; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Gomez J; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia., Kumari N; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Motazedian A; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Chan KL; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia., Bell CC; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Gilan O; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia., Chan YC; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Popp S; The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia., Gough DJ; Department of Molecular Translational Science, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia.; Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, Victoria, Australia., Eckersley-Maslin MA; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Department of Anatomy and Physiology, University of Melbourne, Melbourne, Victoria, Australia., Dawson SJ; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Centre for Cancer Research, University of Melbourne, Melbourne, Victoria, Australia., Lehner PJ; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK., Sutherland KD; ACRF Cancer Biology and Stem Cells Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia., Ernst P; Section of Hematology, Oncology and Bone Marrow Transplant, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., McGeehan GM; Syndax Pharmaceuticals, Waltham, MA, USA., Lam EYN; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia., Burr ML; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. marian.burr@anu.edu.au.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia. marian.burr@anu.edu.au.; The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia. marian.burr@anu.edu.au.; Department of Anatomical Pathology, ACT Pathology, Canberra Health Services, Canberra, Australian Capital Territory, Australia. marian.burr@anu.edu.au., Dawson MA; Cancer Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. mark.dawson@petermac.org.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia. mark.dawson@petermac.org.; Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Victoria, Australia. mark.dawson@petermac.org.; Centre for Cancer Research, University of Melbourne, Melbourne, Victoria, Australia. mark.dawson@petermac.org.
Source: Nature cell biology [Nat Cell Biol] 2023 Feb; Vol. 25 (2), pp. 258-272. Date of Electronic Publication: 2023 Jan 12.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-4679
DOI:10.1038/s41556-022-01056-x