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Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.

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Title: Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.
Authors: Fortin J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Chiang MF; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Meydan C; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065.; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY 10065., Foox J; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065., Ramachandran P; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Leca J; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Lemonnier F; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Institut Mondor de Recherche Biomédicale, INSERMU955, Université Paris Est Créteil, Créteil 94010, France., Li WY; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China., Gams MS; Department of Immunology, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON M5G 0A4, Canada., Sakamoto T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan., Chu M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Tobin C; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Laugesen E; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Robinson TM; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065., You-Ten A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Butler DJ; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065., Berger T; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Minden MD; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada., Levine RL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065., Guidos CJ; Department of Immunology, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON M5G 0A4, Canada., Melnick AM; Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10021., Mason CE; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065.; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY 10065., Mak TW; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China.; Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jan 24; Vol. 120 (4), pp. e2208176120. Date of Electronic Publication: 2023 Jan 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.
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  Data: <searchLink fieldCode="AU" term="%22Fortin+J%22">Fortin J</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.<br /><searchLink fieldCode="AU" term="%22Chiang+MF%22">Chiang MF</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.<br /><searchLink fieldCode="AU" term="%22Meydan+C%22">Meydan C</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065.; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY 10065.<br /><searchLink fieldCode="AU" term="%22Foox+J%22">Foox J</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065.<br /><searchLink fieldCode="AU" term="%22Ramachandran+P%22">Ramachandran P</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.<br /><searchLink fieldCode="AU" term="%22Leca+J%22">Leca J</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.<br /><searchLink fieldCode="AU" term="%22Lemonnier+F%22">Lemonnier F</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Institut Mondor de Recherche Biomédicale, INSERMU955, Université Paris Est Créteil, Créteil 94010, France.<br /><searchLink fieldCode="AU" term="%22Li+WY%22">Li WY</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Gams+MS%22">Gams MS</searchLink>; Department of Immunology, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Sakamoto+T%22">Sakamoto T</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.<br /><searchLink fieldCode="AU" term="%22Chu+M%22">Chu M</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.<br /><searchLink fieldCode="AU" term="%22Tobin+C%22">Tobin C</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.<br /><searchLink fieldCode="AU" term="%22Laugesen+E%22">Laugesen E</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.<br /><searchLink fieldCode="AU" term="%22Robinson+TM%22">Robinson TM</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065.<br /><searchLink fieldCode="AU" term="%22You-Ten+A%22">You-Ten A</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.<br /><searchLink fieldCode="AU" term="%22Butler+DJ%22">Butler DJ</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065.<br /><searchLink fieldCode="AU" term="%22Berger+T%22">Berger T</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.<br /><searchLink fieldCode="AU" term="%22Minden+MD%22">Minden MD</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.<br /><searchLink fieldCode="AU" term="%22Levine+RL%22">Levine RL</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065.; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065.<br /><searchLink fieldCode="AU" term="%22Guidos+CJ%22">Guidos CJ</searchLink>; Department of Immunology, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Melnick+AM%22">Melnick AM</searchLink>; Department of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10021.<br /><searchLink fieldCode="AU" term="%22Mason+CE%22">Mason CE</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10065.; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY 10065.<br /><searchLink fieldCode="AU" term="%22Mak+TW%22">Mak TW</searchLink>; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.; Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong SAR, China.; Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2023 Jan 24; Vol. 120 (4), pp. e2208176120. <i>Date of Electronic Publication: </i>2023 Jan 18.
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