Phase I Study of Single-Agent Anti-Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates.

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Title: Phase I Study of Single-Agent Anti-Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates.
Authors: Brahmer JR; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Drake CG; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Wollner I; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Powderly JD; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Picus J; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Sharfman WH; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Stankevich E; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Pons A; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Salay TM; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., McMiller TL; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Gilson MM; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Wang C; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Selby M; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Taube JM; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Anders R; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Chen L; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Korman AJ; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Pardoll DM; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Lowy I; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA., Topalian SL; From the Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; Henry Ford Health Systems, Detroit, MI; Carolina BioOncology Institute, Huntersville, NC; Washington University School of Medicine Siteman Cancer Center, St Louis, MO; and Medarex, Bloomsbury, NJ, and Milpitas, CA.
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2023 Feb 01; Vol. 41 (4), pp. 715-723.
Publication Type: Journal Article; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't; Multicenter Study
Journal Info: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE; PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1527-7755
DOI:10.1200/JCO.22.02270