The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.

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Title: The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function.
Authors: Singer MR; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom., Dinh T; Division of Infectious Diseases, School of Medicine, University of Colorado, Aurora, Colorado, USA., Levintov L; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA., Annamalai AS; Division of Infectious Diseases, School of Medicine, University of Colorado, Aurora, Colorado, USA., Rey JS; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA., Briganti L; Division of Infectious Diseases, School of Medicine, University of Colorado, Aurora, Colorado, USA., Cook NJ; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom., Pye VE; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom., Taylor IA; Macromolecular Structure Laboratory, The Francis Crick Institute, London, United Kingdom., Kim K; ST Pharm Co. Ltd., Seoul, South Korea., Engelman AN; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Kim B; Center for Drug Discovery, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.; Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, USA., Perilla JR; Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware, USA., Kvaratskhelia M; Division of Infectious Diseases, School of Medicine, University of Colorado, Aurora, Colorado, USA., Cherepanov P; Chromatin Structure & Mobile DNA Laboratory, The Francis Crick Institute, London, United Kingdom.; Department of Infectious Disease, St-Mary's Campus, Imperial College London, London, United Kingdom.
Source: MBio [mBio] 2023 Feb 28; Vol. 14 (1), pp. e0356022. Date of Electronic Publication: 2023 Feb 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2150-7511
DOI:10.1128/mbio.03560-22