Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.

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Title: Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.
Authors: Nguyen TP; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Wang W; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Sternisha AC; Children's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Corley CD; Center for Human Nutrition, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Wang HL; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Wang X; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Ortiz F; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Lim SK; Department of Development Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Abdullah KG; Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Parada LF; Department of Development Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Williams NS; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., McBrayer SK; Children's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., McDonald JG; Center for Human Nutrition, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., De Brabander JK; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: jef.debrabander@utsouthwestern.edu., Nijhawan D; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, Program in Molecular Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: deepak.nijhawan@utsouthwestern.edu.
Source: Cell chemical biology [Cell Chem Biol] 2023 Feb 16; Vol. 30 (2), pp. 214-229.e18. Date of Electronic Publication: 2023 Feb 08.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2451-9448
DOI:10.1016/j.chembiol.2023.01.005