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Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.

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Title: Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.
Authors: Nguyen TP; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Wang W; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Sternisha AC; Children's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Corley CD; Center for Human Nutrition, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Wang HL; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Wang X; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Ortiz F; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Lim SK; Department of Development Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Abdullah KG; Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Parada LF; Department of Development Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Williams NS; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., McBrayer SK; Children's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., McDonald JG; Center for Human Nutrition, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., De Brabander JK; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: jef.debrabander@utsouthwestern.edu., Nijhawan D; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, Program in Molecular Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: deepak.nijhawan@utsouthwestern.edu.
Source: Cell chemical biology [Cell Chem Biol] 2023 Feb 16; Vol. 30 (2), pp. 214-229.e18. Date of Electronic Publication: 2023 Feb 08.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.
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  Data: <searchLink fieldCode="AU" term="%22Nguyen+TP%22">Nguyen TP</searchLink>; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Sternisha+AC%22">Sternisha AC</searchLink>; Children's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Corley+CD%22">Corley CD</searchLink>; Center for Human Nutrition, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Wang+HL%22">Wang HL</searchLink>; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Ortiz+F%22">Ortiz F</searchLink>; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Lim+SK%22">Lim SK</searchLink>; Department of Development Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Abdullah+KG%22">Abdullah KG</searchLink>; Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Parada+LF%22">Parada LF</searchLink>; Department of Development Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22Williams+NS%22">Williams NS</searchLink>; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22McBrayer+SK%22">McBrayer SK</searchLink>; Children's Medical Center Research Institute and Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22McDonald+JG%22">McDonald JG</searchLink>; Center for Human Nutrition, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.<br /><searchLink fieldCode="AU" term="%22De+Brabander+JK%22">De Brabander JK</searchLink>; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: jef.debrabander@utsouthwestern.edu.<br /><searchLink fieldCode="AU" term="%22Nijhawan+D%22">Nijhawan D</searchLink>; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Internal Medicine, Program in Molecular Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: deepak.nijhawan@utsouthwestern.edu.
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  Data: <searchLink fieldCode="JN" term="%22101676030%22">Cell chemical biology</searchLink> [Cell Chem Biol] 2023 Feb 16; Vol. 30 (2), pp. 214-229.e18. <i>Date of Electronic Publication: </i>2023 Feb 08.
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        Value: 10.1016/j.chembiol.2023.01.005
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              Text: 2023 Feb 16
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