Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes.

Saved in:
Bibliographic Details
Title: Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes.
Authors: Karczewski KJ; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Solomonson M; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Chao KR; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Goodrich JK; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Tiao G; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Lu W; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Riley-Gillis BM; Genomics Research Center, AbbVie, North Chicago, IL 60064, USA., Tsai EA; Biogen, Inc., Cambridge, MA 02142, USA., Kim HI; Worldwide Research Development and Medical, Pfizer, Inc., Cambridge, MA 02139, USA., Zheng X; Genomics Research Center, AbbVie, North Chicago, IL 60064, USA., Rahimov F; Genomics Research Center, AbbVie, North Chicago, IL 60064, USA., Esmaeeli S; Genomics Research Center, AbbVie, North Chicago, IL 60064, USA., Grundstad AJ; Genomics Research Center, AbbVie, North Chicago, IL 60064, USA., Reppell M; Genomics Research Center, AbbVie, North Chicago, IL 60064, USA., Waring J; Genomics Research Center, AbbVie, North Chicago, IL 60064, USA., Jacob H; Genomics Research Center, AbbVie, North Chicago, IL 60064, USA., Sexton D; Biogen, Inc., Cambridge, MA 02142, USA., Bronson PG; Biogen, Inc., Cambridge, MA 02142, USA., Chen X; Worldwide Research Development and Medical, Pfizer, Inc., Cambridge, MA 02139, USA., Hu X; Worldwide Research Development and Medical, Pfizer, Inc., Cambridge, MA 02139, USA., Goldstein JI; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., King D; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Vittal C; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Poterba T; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Palmer DS; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Churchhouse C; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Howrigan DP; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Zhou W; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Watts NA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Nguyen K; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Nguyen H; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Mason C; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Farnham C; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Tolonen C; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Gauthier LD; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Gupta N; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., MacArthur DG; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Rehm HL; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA., Seed C; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Philippakis AA; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Daly MJ; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Institute for Molecular Medicine Finland, Helsinki, Finland., Davis JW; Genomics Research Center, AbbVie, North Chicago, IL 60064, USA., Runz H; Biogen, Inc., Cambridge, MA 02142, USA., Miller MR; Worldwide Research Development and Medical, Pfizer, Inc., Cambridge, MA 02139, USA., Neale BM; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Source: Cell genomics [Cell Genom] 2022 Aug 15; Vol. 2 (9), pp. 100168. Date of Electronic Publication: 2022 Aug 15 (Print Publication: 2022).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-979X
DOI:10.1016/j.xgen.2022.100168