Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19.
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| Title: | Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19. |
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| Authors: | Zhu B; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Wei X; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Narasimhan H; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA., Qian W; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA., Zhang R; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Cheon IS; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Wu Y; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Li C; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA., Jones RG; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Kaplan MH; Department of Microbiology and Immunology, Indiana University of School of Medicine, Indianapolis, IN 46202, USA., Vassallo RA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA., Braciale TJ; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA., Somerville L; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA., Colca JR; Cirius Therapeutics, Kalamazoo, MI 49007, USA., Pandey A; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.; Manipal Academy of Higher Education, Manipal-576 104, Karnataka, India., Jackson PEH; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA., Mann BJ; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA., Krawczyk CM; Department of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI 49503, USA., Sturek JM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA., Sun J; Carter Immunology Center, University of Virginia, Charlottesville, VA 22908, USA.; Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA.; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.; Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA. |
| Source: | Science immunology [Sci Immunol] 2023 Apr 14; Vol. 8 (82), pp. eadf0348. Date of Electronic Publication: 2023 Apr 14. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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