Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism.

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Title: Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism.
Authors: Upadhyayula PS; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA., Higgins DM; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA., Mela A; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA., Banu M; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA., Dovas A; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA., Zandkarimi F; Department of Chemistry, Columbia University, New York, NY, USA., Patel P; Department of Proteomics and Macromolecular Crystallography, Columbia University Medical Center, New York, NY, USA., Mahajan A; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA., Humala N; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA., Nguyen TTT; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA., Chaudhary KR; Department of Radiation Oncology, Columbia University Medical Center, New York, NY, USA., Liao L; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA., Argenziano M; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA., Sudhakar T; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA., Sperring CP; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA., Shapiro BL; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA., Ahmed ER; Department of Biological Sciences, Columbia University, New York, NY, USA., Kinslow C; Department of Chemistry, Columbia University, New York, NY, USA., Ye LF; Department of Medicine, Columbia University Medical Center, New York, NY, USA., Siegelin MD; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA., Cheng S; Department of Chemistry, Columbia University, New York, NY, USA., Soni R; Department of Proteomics and Macromolecular Crystallography, Columbia University Medical Center, New York, NY, USA., Bruce JN; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA., Stockwell BR; Department of Chemistry, Columbia University, New York, NY, USA.; Department of Biological Sciences, Columbia University, New York, NY, USA., Canoll P; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA. pc561@cumc.columbia.edu.
Source: Nature communications [Nat Commun] 2023 Mar 02; Vol. 14 (1), pp. 1187. Date of Electronic Publication: 2023 Mar 02.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-023-36630-w