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CDK4/6 inhibition triggers ICAM1-driven immune response and sensitizes LKB1 mutant lung cancer to immunotherapy.

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Title: CDK4/6 inhibition triggers ICAM1-driven immune response and sensitizes LKB1 mutant lung cancer to immunotherapy.
Authors: Bai X; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China., Guo ZQ; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China., Zhang YP; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.; Information Management and Big Data Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Fan ZZ; CAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China National Center for Bioinformation, Beijing, 100101, China.; Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes and MOE Key Laboratory of Tumor Molecular Biology, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou, China., Liu LJ; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou, 510515, Guangdong Province, China., Liu L; Information Management and Big Data Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Department of Medical Quality Management, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Long LL; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China., Ma SC; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.; Information Management and Big Data Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Wang J; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China., Fang Y; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China., Tang XR; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China., Zeng YJ; The First Clinical Medical College, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China., Pan X; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou, 510515, Guangdong Province, China. PanVictor@SMU.edu.cn., Wu DH; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China. 18602062748@163.com., Dong ZY; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China. dongzy1317@foxmail.com.
Source: Nature communications [Nat Commun] 2023 Mar 04; Vol. 14 (1), pp. 1247. Date of Electronic Publication: 2023 Mar 04.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: CDK4/6 inhibition triggers ICAM1-driven immune response and sensitizes LKB1 mutant lung cancer to immunotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Bai+X%22">Bai X</searchLink>; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Guo+ZQ%22">Guo ZQ</searchLink>; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YP%22">Zhang YP</searchLink>; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.; Information Management and Big Data Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Fan+ZZ%22">Fan ZZ</searchLink>; CAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China National Center for Bioinformation, Beijing, 100101, China.; Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes and MOE Key Laboratory of Tumor Molecular Biology, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Liu+LJ%22">Liu LJ</searchLink>; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou, 510515, Guangdong Province, China.<br /><searchLink fieldCode="AU" term="%22Liu+L%22">Liu L</searchLink>; Information Management and Big Data Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.; Department of Medical Quality Management, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Long+LL%22">Long LL</searchLink>; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Ma+SC%22">Ma SC</searchLink>; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.; Information Management and Big Data Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Fang+Y%22">Fang Y</searchLink>; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Tang+XR%22">Tang XR</searchLink>; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Zeng+YJ%22">Zeng YJ</searchLink>; The First Clinical Medical College, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Pan+X%22">Pan X</searchLink>; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou, 510515, Guangdong Province, China. PanVictor@SMU.edu.cn.<br /><searchLink fieldCode="AU" term="%22Wu+DH%22">Wu DH</searchLink>; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China. 18602062748@163.com.<br /><searchLink fieldCode="AU" term="%22Dong+ZY%22">Dong ZY</searchLink>; Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, 510515, China. dongzy1317@foxmail.com.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2023 Mar 04; Vol. 14 (1), pp. 1247. <i>Date of Electronic Publication: </i>2023 Mar 04.
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