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Programmed Cell Death-1 (PD-1) anchoring to the GPI-linked co-receptor CD48 reveals a novel mechanism to modulate PD-1-dependent inhibition of human T cells.

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Title: Programmed Cell Death-1 (PD-1) anchoring to the GPI-linked co-receptor CD48 reveals a novel mechanism to modulate PD-1-dependent inhibition of human T cells.
Authors: White D; Departments of Immunology and Respiratory Research, USA. Electronic address: della.white@boehringer-ingelheim.com., Cote-Martin A; Departments of Immunology and Respiratory Research, USA., Bleck M; Departments of Immunology and Respiratory Research, USA., Garaffa N; Cancer Immunology and Immune Modulation, USA., Shaaban A; Cancer Immunology and Immune Modulation, USA., Wu H; Biotherapeutics Discovery. Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT 06811 USA., Liu D; Biotherapeutics Discovery. Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT 06811 USA., Young D; Biotherapeutics Discovery. Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT 06811 USA., Scheer J; Biotherapeutics Discovery. Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT 06811 USA., Lorenz IC; Biotherapeutics Discovery. Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT 06811 USA., Nixon A; Biotherapeutics Discovery. Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT 06811 USA., Fine JS; Departments of Immunology and Respiratory Research, USA., Byrne FR; Departments of Immunology and Respiratory Research, USA., Mbow ML; Departments of Immunology and Respiratory Research, USA; Cancer Immunology and Immune Modulation, USA., Moreno-Garcia ME; Departments of Immunology and Respiratory Research, USA. Electronic address: morgarmig@gmail.com.
Source: Molecular immunology [Mol Immunol] 2023 Apr; Vol. 156, pp. 31-38. Date of Electronic Publication: 2023 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 7905289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9142 (Electronic) Linking ISSN: 01615890 NLM ISO Abbreviation: Mol Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-9142
DOI:10.1016/j.molimm.2023.02.007