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CRISPR/Cas9 Screen in Gastric Cancer Patient-Derived Organoids Reveals KDM1A-NDRG1 Axis as a Targetable Vulnerability.

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Title: CRISPR/Cas9 Screen in Gastric Cancer Patient-Derived Organoids Reveals KDM1A-NDRG1 Axis as a Targetable Vulnerability.
Authors: Mircetic J; German Cancer Consortium (DKTK), Partner Site Dresden, German Cancer Research Center (DKFZ), 01309, Dresden, Germany.; Mildred Scheel Early Career Center (MSNZ) P2, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany., Camgöz A; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), 01307, Dresden, Germany.; German Cancer Research Center (DKFZ), 01307, Heidelberg, Germany.; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.; Helmholtz-Zentrum Dresden - Rossendorf (HZDR), 01307, Dresden, Germany., Abohawya M; German Cancer Consortium (DKTK), Partner Site Dresden, German Cancer Research Center (DKFZ), 01309, Dresden, Germany., Ding L; Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany., Dietzel J; Mildred Scheel Early Career Center (MSNZ) P2, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany., Tobar SG; Mildred Scheel Early Career Center (MSNZ) P2, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany., Paszkowski-Rogacz M; Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany., Seidlitz T; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany., Schmäche T; National Center for Tumor Diseases (NCT), 01307, Dresden, Germany.; German Cancer Research Center (DKFZ), 01307, Heidelberg, Germany.; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.; Helmholtz-Zentrum Dresden - Rossendorf (HZDR), 01307, Dresden, Germany.; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany., Mehnert MC; Mildred Scheel Early Career Center (MSNZ) P2, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany., Sidorova O; Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.; Experimental and Clinical Research Center (ECRC) of the Max Delbrück Center (MDC) and Charité Berlin, 10117, Berlin, Germany., Weitz J; National Center for Tumor Diseases (NCT), 01307, Dresden, Germany.; German Cancer Research Center (DKFZ), 01307, Heidelberg, Germany.; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.; Helmholtz-Zentrum Dresden - Rossendorf (HZDR), 01307, Dresden, Germany.; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany., Buchholz F; National Center for Tumor Diseases (NCT), 01307, Dresden, Germany.; German Cancer Research Center (DKFZ), 01307, Heidelberg, Germany.; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.; Helmholtz-Zentrum Dresden - Rossendorf (HZDR), 01307, Dresden, Germany.; Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany., Stange DE; German Cancer Consortium (DKTK), Partner Site Dresden, German Cancer Research Center (DKFZ), 01309, Dresden, Germany.; National Center for Tumor Diseases (NCT), 01307, Dresden, Germany.; German Cancer Research Center (DKFZ), 01307, Heidelberg, Germany.; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.; Helmholtz-Zentrum Dresden - Rossendorf (HZDR), 01307, Dresden, Germany.; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.
Source: Small methods [Small Methods] 2023 Jun; Vol. 7 (6), pp. e2201605. Date of Electronic Publication: 2023 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 101724536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2366-9608 (Electronic) Linking ISSN: 23669608 NLM ISO Abbreviation: Small Methods Subsets: MEDLINE
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  Data: CRISPR/Cas9 Screen in Gastric Cancer Patient-Derived Organoids Reveals KDM1A-NDRG1 Axis as a Targetable Vulnerability.
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  Data: <searchLink fieldCode="AU" term="%22Mircetic+J%22">Mircetic J</searchLink>; German Cancer Consortium (DKTK), Partner Site Dresden, German Cancer Research Center (DKFZ), 01309, Dresden, Germany.; Mildred Scheel Early Career Center (MSNZ) P2, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Camgöz+A%22">Camgöz A</searchLink>; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), 01307, Dresden, Germany.; German Cancer Research Center (DKFZ), 01307, Heidelberg, Germany.; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.; Helmholtz-Zentrum Dresden - Rossendorf (HZDR), 01307, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Abohawya+M%22">Abohawya M</searchLink>; German Cancer Consortium (DKTK), Partner Site Dresden, German Cancer Research Center (DKFZ), 01309, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Ding+L%22">Ding L</searchLink>; 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Medical Systems Biology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.; Experimental and Clinical Research Center (ECRC) of the Max Delbrück Center (MDC) and Charité Berlin, 10117, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Weitz+J%22">Weitz J</searchLink>; National Center for Tumor Diseases (NCT), 01307, Dresden, Germany.; German Cancer Research Center (DKFZ), 01307, Heidelberg, Germany.; Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.; Helmholtz-Zentrum Dresden - Rossendorf (HZDR), 01307, Dresden, Germany.; Department of Visceral, Thoracic and Vascular Surgery, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Buchholz+F%22">Buchholz F</searchLink>; National Center for Tumor Diseases (NCT), 01307, Dresden, Germany.; German Cancer Research Center (DKFZ), 01307, Heidelberg, Germany.; 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